毛茛科中C_(20)-二萜生物碱及其生物活性研究进展  

Research progress on C_(20)-diterpenoid alkaloids and their bioactivities in Ranunculaceae

作　　者：李东旭 续洁琨 殷伟峰 张帆[4] 朱海 王东格 丁康 潘雪格 李玲芝[2] 赫军[1] 张维库[1] LI Dong-xu;XU Jie-kun;YIN Wei-feng;ZHANG Fan;ZHU Hai;WANG Dong-ge;DING Kang;PAN Xue-ge;LI Ling-zhi;HE Jun;ZHANG Wei-ku(Department of Pharmacy&Institute of Clinical Medical Sciences,China-Japan Friendship Hospital,Bejing 100029,China;School of Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 117004,China;School of Life Sciences,Beijing University of Chinese Medicine,Beijing 100029,China;School of Chinese Materia Medica,Bejing University of Chinese Medicine,Bejing 100029,China)

机构地区：[1]中日友好医院药学部&临床医学研究所,北京100029 [2]沈阳药科大学中药学院,辽宁沈阳117004 [3]北京中医药大学生命科学学院,北京100029 [4]北京中医药大学中药学院,北京100029

出　　处：《中国中药杂志》2024年第15期4054-4068,共15页China Journal of Chinese Materia Medica

基　　金：中央高水平医院临床科研业务费项目&中日友好医院菁英计划(2023-NHLHCRF-CXYW-01,ZRJY2024-BJ01);国家自然科学基金项目(82073731,82273815,82273809)。

摘　　要：C_(20)-二萜生物碱在毛茛科中主要分布在乌头属、翠雀属和飞燕草属植物中,其化学结构类型主要分为阿替生型、光翠雀碱型、海替定型和海替生型等9种类型。生物活性研究表明该类化合物在抗肿瘤、镇痛、抗心律失常和抗炎等方面均表现出较好的活性。该文对2002年至今从毛茛科植物中报道的190个C_(20)-二萜生物碱的化学结构和生物活性进行了总结,以期对毛茛科植物中C_(20)-二萜生物碱的研究提供参考。C_(20)-diterpenoid alkaloids are mainly distributed in plants of genus Aconitum,Delphinium,and Consolida in the Ranunculaceae.Their chemical structures are mainly categorized into nine types such as atisines,denudatines,hetidines,and hetisines.Bioactivity studies have shown that C_(20)-diterpenoid alkaloids have exhibited superior anti-tumor,analgesic,antiarrhythmic,and anti-inflammatory effects.In this review,the chemical structures and biological activities of 190 C_(20)-diterpenoid alkaloids reported in the Ranunculaceae from 2002 to the present were summarized,so as to provide a reference for the subsequent research on C_(20)-diterpenoid alkaloids in plants of Ranunculaceae.

关 键 词：毛茛科 C_(20)-二萜生物碱 乌头属 翠雀属 飞燕草属 

分 类 号：R284[医药卫生—中药学]