Dynamic kinetic stereodivergent transformations of propargylic ammonium salts via dual nickel and copper catalysis  

作　　者：Ruilong Geng Lingzi Peng Chang Guo 

机构地区：[1]Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry,University of Science and Technology of China,Hefei 230026,China

出　　处：《Chinese Chemical Letters》2024年第8期265-269,共5页中国化学快报（英文版）

基　　金：support from the National Natural Science Foundation of China(Nos.21702198,21971227);the Anhui Provincial Natural Science Foundation(No.1808085MB30);the Fundamental Research Funds for the Central Universities(No.WK2340000090).

摘　　要：The dynamic kinetic asymmetric transformation of racemic propargylic ammonium salts with prochiral aldimine esters through a stereodivergent propargylation is catalyzed by dual nickel and copper catalysis.Thus,a diverse range of optically activeα-quaternary amino esters were produced via C-N bond cleavage with high reaction efficiency and stereoselectivity(up to>99%ee).By selection of the appropriate pair-wise combination of catalyst configurational isomers,all four possible stereoisomers of the corresponding propargylation products are obtained in high yields with excellent regio-,diastereo-,and enantioselectiv-ities.

关 键 词：Stereodivergent propargylation Dual catalysis C-N bond cleavage Azaomethine ylides Internal propargylic ammonium salts Excellent stereoselectivity 

分 类 号：TQ226.36[化学工程—有机化工]