One stone three birds:Ni-catalyzed asymmetric allenylic substitution of allenic ethers,hydroalkylation of 1,3-enynes and double alkylation of enynyl ethers  

作　　者：Zhirong Yang Shan Wang Ming Jiang Gengchen Li Long Li Fangzhi Peng Zhihui Shao 

机构地区：[1]Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,School of Chemical Science and Technology,Yunnan Provincial Center for Research&Development of Natural Products,and State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan,Yunnan University,Kunming 650091,China

出　　处：《Chinese Chemical Letters》2024年第8期282-287,共6页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No.22171240)

摘　　要：The development of low-cost,earth-abundant and environmentally benign transition metal catalysts,which can catalyze multiple different types of asymmetric reactions,is an important objective in mod-ern asymmetric catalysis.Herein we demonstrate that a chiral Ni/P-Phos catalyst achieves three types of asymmetric reactions:allenylic substitution of racemic allenic ethers,1,4-hydroalkylation of prochiral 1,3-enynes and double alkylation of newly designed enynyl ether reagents.Three methods complement each other and produce various axially chiral allene derivatives bearing a pyrazolidine-3,5-dione unit,which is widely present in drugs and biologically active molecules with versatile pharmacological activities.

关 键 词：Nickel Asymmetric catalysis Allenylic substitution HYDROALKYLATION Double alkylation Allene 1 3-Enyne Pyrazolidine-3 5-dione 

分 类 号：O621.251[理学—有机化学]