Citrinsorbicillin A,a novel homotrimeric sorbicillinoid isolated by LC-MS-guided with cytotoxic activity from the fungus Trichoderma citrinoviride HT-9  

作　　者：Guo-Ping Yin Ya-Juan Li Li Zhang Ling-Gao Zeng Xue-Mei Liu Chang-Hua Hu 

机构地区：[1]Engineering Research Center of Coptis Development and Utilization(Ministry of Education),College of Pharmaceutical Sciences and Chinese Medicine,Southwest University,Chongqing 400715,China [2]State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 211198,China [3]NMPA Key Laboratory for Quality Monitoring of Narcotic Drugs and Psychotropic Substances,Chongqing Institute for Food and Drug Control,Chongqing 401121,China

出　　处：《Chinese Chemical Letters》2024年第8期299-303,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.82003629);the Natural Science Foundation of Chongqing(No.cstc2021jcyj-msxmX0975);the Open Project of State Key Laboratory of Natural Medicines(No.SKLNMKF202304).

摘　　要：Citrinsorbicillin A(1),a novel homotrimeric sorbicillinoid,along with two new monomers citrinsor-bicillins B(2)and C(3),were isolated from the Coptis chinensis endophyte Trichoderma citrinoviride HT-9 by liquid chromatograph mass spectrometer(LC-MS)-guided strategy.1 was the first trimeric-example from terrestrial fungi,which possessed a unique carbon skeleton with two bicyclo[2.2.2]octanedione ring connected through an enolated carbon forming by[4+2]cycloaddition.Their structures were elucidated by spectroscopic analysis and X-ray diffraction.1 exhibited moderate cytotoxicity against human colon cancer HT29 cells,and it induced significant cell cycle arrest by reducing the protein expression of cyclin D1.

关 键 词：Citrinsorbicillin A Trimeric sorbicillinoid Coptis chinensis endophyte Trichoderma citrinoviride [4+2]Cycloaddition Cytotoxic activity 

分 类 号：Q936[生物学—微生物学] O657.63[理学—分析化学]