Cocktail effect of ionic patch driven by triboelectric nanogenerator for diabetic wound healing  

作　　者：Yixia Zhang Caili Xue Yunpeng Zhang Qi Zhang Kai Zhang Yulin Liu Zhaohui Shan Wu Qiu Gang Chen Na Li Hulin Zhang Jiang Zhao Da-Peng Yang 

机构地区：[1]College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,China [2]College of Electronic Information and Optical Engineering,Taiyuan University of Technology,Taiyuan 030024,China [3]Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering,Taiyuan 030024,China [4]College of Integrated Circuit Science and Engineering,Nanjing University of Posts and Telecommunications,Nanjing 210023,China [5]School of Rehabilitation Science and Engineering,University of Health and Rehabilitation Sciences,Qingdao 266024,China [6]School of Materials and Chemical Engineering,Quanzhou Normal University,Quanzhou 362000,China

出　　处：《Chinese Chemical Letters》2024年第8期460-465,共6页中国化学快报（英文版）

基　　金：supported financially by the Natural Science Foundation of Shanxi Province Grants(No.202203021211157);Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(No.2023SX-FR006);The Science and Technology Major Special Plan Project“Reveal the Tile”of Quanzhou Province(No.2022NZ1).

摘　　要：There is increasing evidence shows that either electrical stimulation(ES)or metal ion is an effective way to accelerate ulcerative wound healing.However,less attention is paid to investigating the synergistic effect between them.Herein,we explore the combined effects of ES and multiple metal ions on dia-betic wound healing assisted by a triboelectric nanogenerator(TENG).Firstly,the novel Eggshell@CuFe_(2)O_(4)nanocomposites(NCs)are prepared,which show unique structure and intrinsic antimicrobial properties.Subsequently,the as-prepared nanocomposites are embedded in oxidized starch hydrogel to form a mul-tifunctional composite gel,which is further assembled into a wearable ionic triboelectric nanogenerator(iTENG)patch with polydimethylsiloxane(PDMS).It can convert the mechanical energy produced by a human body motion to electric energy and mediate the sequential release of metal ions(Fe^(2+)/Ca^(2+)/Cu^(2+)),thereby resulting in the“cocktail effect”on impaired tissue.Under their effects,a satisfying healing re-sult in diabetic mouse is identified,which can effectively accelerate wound healing process by relieving inflammation,promoting angiogenesis and collagen deposition.The work puts forward the cocktail effect of electric simulation coupled with the multiple metal ions,and opens up a new perspective in designing iTENG patch towards repair of hard-to-heal wounds.

关 键 词：iTENG Cocktail effect CuFe_(2)O_(4) EGGSHELL Diabetic wound 

分 类 号：TQ427.26[化学工程] R587.1[医药卫生—内分泌]