生物毒素抗病毒作用的研究进展  

Research progress of biotoxins in the antiviral field

作　　者：佘梓荧 曹程 周进 SHE Zi-Ying;CAO Cheng;ZHOU Jin(Institute of Ocean Engineering,Tsinghua Shenzhen International Graduate School,Shenzhen 518055,China)

机构地区：[1]清华大学深圳国际研究生院,海洋工程研究院,深圳518055

出　　处：《生命科学》2024年第7期877-886,共10页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(41976126);广东省普通高校创新团队项目(自然科学)(2023KCXTD052);深圳市科技计划(KCXFZ20230731093402005)。

摘　　要：随着全球病毒多样性的增加和变异速度的加快,现有疫苗和抗病毒药物防控方法面临巨大挑战,因此急需开发新型抗病毒药物以缓解这一压力。在这种情况下,生物毒素的开发带来了曙光,各类生物毒素(蜂毒、蛇毒、蝎毒、藻毒素等)表现出很强的抗病毒活性,具有成为新型抗病毒药物的潜力。基于此,本文以近10年的文献为重点,综述了主要天然毒素的有效成分、抗病毒机制和应用情况,并对生物毒素的成药机遇和挑战进行了展望。With the increasing viral diversity and their mutation probability globally,the current methods(such as vaccines and antiviral therapies)are facing great challenges.Therefore,it is urgent for us to develop novel antiviral drugs.Under such circumstances,various types of biotoxins(for example bee venom,snake venom,scorpion venom,and algal toxins,etc.)show antiviral potential and can act as new candidates for antiviral drug resources.Based on this,we review the active ingredients,antiviral mechanisms,and possible applications of major biotoxins over the past 10 years.In addition,we provide an outlook on the opportunities and challenges of biotoxin drugs,hoping to gather new ideas for the development of antiviral drugs.

关 键 词：生物毒素 抗病毒活性 新型药物 开发潜力 

分 类 号：Q939.4[生物学—微生物学] R99[医药卫生—毒理学]