CD8^(+)T细胞在肝细胞癌中的耗竭机制  

The mechanism of CD8^(+)T cell exhaustion in hepatocellular carcinoma

作　　者：荆郭 詹天诚 宋万骞 袁永康 康宁[1] 张强 JING Guo;ZHAN Tian-Cheng;SONG Wan-Qian;YUAN Yong-Kang;KANG Ning;ZHANG Qiang(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学,天津301617

出　　处：《生命科学》2024年第7期887-897,共11页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(82104461,8227-4221);国家级大学生创新创业训练计划项目(20231-0063010)。

摘　　要：在肝细胞癌(hepatocellular carcinoma,HCC)中,抗原的持续刺激会使CD8^(+)T细胞呈现耗竭状态,具体表现为CD8^(+)T细胞表面抑制性受体(inhibitory receptors,IRs)持续性表达上调及共表达、表观遗传和转录谱发生改变,以及代谢呈现紊乱状态等,导致CD8^(+)T细胞的增殖功能衰退,免疫功能逐渐丧失,进而引起CD8^(+)T细胞死亡,最终使肿瘤细胞发生免疫逃逸。本文综述了目前对CD8^(+)T细胞耗竭特征及机制的最新研究进展,为靶向耗竭CD8^(+)T细胞的HCC免疫治疗提供借鉴。Under continuous antigen stimulation in hepatocellular carcinoma,CD8^(+)T cells undergo an exhausted state through various mechanisms,which is characterized by sustained upregulation and co-expression of inhibitory receptors on the surface of CD8^(+)T cells,as well as changes in epigenetic and transcriptional profiles,and metabolic disorders.These factors cause impaired proliferation function of CD8^(+)T cells,progressive loss of immune function,and ultimately CD8^(+)T cell death,resulting in immune escape of tumor cells.This article provides a review of the latest research progress on the occurrence,development,characteristics,and potential mechanisms of CD8^(+)T cell exhaustion in hepatocellular carcinoma.It aims to serve as a reference for further mechanism research and targeted treatment of CD8^(+)T cell exhaustion in hepatocellular carcinoma.

关 键 词：CD8^(+)T细胞耗竭 肝细胞癌 抑制性受体 肿瘤微环境 

分 类 号：R392.12[医药卫生—免疫学] R735.7[医药卫生—基础医学]