TBC蛋白在人类疾病中的研究进展  

Progress of TBC proteins in human diseases

作　　者：罗宇琦 林洁 任骏 LUO Yu-Qi;LIN Jie;REN Jun(Shanghai Medical College,Fudan University,Shanghai 200032,China;Department of Cardiology,Zhongshan Hospital Fudan University,Shanghai Institute of Cardiovascular Disease,Shanghai 200032,China)

机构地区：[1]复旦大学上海医学院,上海200032 [2]复旦大学附属中山医院心内科,上海市心血管病研究所,上海200032

出　　处：《生命科学》2024年第7期898-905,共8页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(82130011,92249301)。

摘　　要：TBC蛋白,作为含Tre2-Bub2-Cdc16(TBC)结构域的GTP酶激活因子,对Rab蛋白的负调控发挥着关键作用。这一结构域集成了Tre2原癌基因、Bub2酵母细胞周期调节蛋白和Cdc16细胞分裂周期基因,显示出高度的进化保守性。通过调节Rab蛋白的GTP-GDP转换循环,TBC蛋白在特异性细胞内运输中扮演着重要角色。它不仅在维持正常细胞生理过程中至关重要,而且其功能异常或突变与多种人类疾病的发生密切相关。该文综述了TBC蛋白的结构特征、生化功能及在人类疾病中作用的最新研究成果,旨在深入理解其在疾病发展中的潜在机制。TBC proteins,as Tre2-Bub2-Cdc16(TBC)structural domain-containing GTPase activators,play a key role in the negative regulation of Rab proteins.This structural domain integrates the Tre2 proto-oncogene,the Bub2 yeast cell cycle regulatory protein,and the Cdc16 cell division cycle gene,showing a high degree of evolutionary conservation.By regulating the GTP-GDP transition cycle of Rab proteins,the TBC proteins play an important role in specific intracellular transport.It is not only essential in maintaining normal cellular physiological processes,but also its abnormal function or mutation is closely associated with the development of several human diseases.In this paper,we review the latest research results on the structural features,biochemical functions and roles of TBC proteins in human diseases,aiming to gain a deeper understanding of their potential mechanisms in disease development.

关 键 词：RAB TBC GTP酶激活蛋白 

分 类 号：Q591.4[生物学—生物化学] Q946.5