类方开心散与定志小丸的化学成分以及药理活性差异研究进展  

Research progress on differences in chemical constituents and pharmacological activities between Lei Fang Kai-Xin-San and Ding-Zhi-Xiao-Wan

作　　者：路启伟 于阔 王春华 颜晓晖 LU Qiwei;YU Kuo;WANG Chunhua;YAN Xiaohui(College of Pharmaceutical Engineering of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300457,China;School of Medicine,Foshan University,Guangdong Foshan 528225,China;Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300457,China)

机构地区：[1]天津中医药大学中药制药工程学院,天津300457 [2]佛山大学医学院,广东佛山528225 [3]天津中医药大学中医药研究院,天津300457

出　　处：《上海中医药大学学报》2024年第4期102-112,共11页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：广东省基础与应用基础研究基金项目(2022B1515120015);广东省普通高校重点领域专项项目(2022ZDZX2056)。

摘　　要：综述类方开心散和定志小丸在化学成分上的差异以及在增强学习记忆、抗氧化、抗抑郁和抗阿尔茨海默病等方面的药理活性研究进展。通过查阅开心散和定志小丸的相关文献,对开心散和定志小丸的化学成分以及药理活性研究进行归纳。结果发现定志小丸是在开心散的基础上改变了药材配伍比例,导致药理活性发生改变;开心散和定志小丸都广泛用于抗抑郁、抗阿尔茨海默病、改善学习记忆能力、抗衰老以及抗疲劳等方面,但是二者发挥作用的机制不同。虽然开心散和定志小丸的化学成分以及药理活性研究取得了一定进展,但学者们多基于基础模型进行实验证明开心散和定志小丸的药理作用,对药效物质基础以及具体作用机制研究较少,有待进一步深入研究。It is to review the differences in chemical constituents between Lei Fang Kai-Xin-San(KXS)and Ding-Zhi-Xiao-Wan(DZXW),and the research progress in pharmacological activities such as enhancing learning and memory,anti-oxidation,anti-depression and anti-Alzheimer disease(AD).The chemical constituents and pharmacological activities of KXS and DZXW were summerized by consulting the related literature.The results showed that the compatibility ratio of medicinal materials of DZXW was changed based on KXS,which led to the change of pharmacological activity.Both KXS and DZXW are widely used in anti-depression,anti-AD,improving learning and memory abilities,anti-aging and anti-fatigue,but their mechanisms are different.Some progress has been made in the study of chemical constituents and pharmacological activities of KXS and DZXW,however,scholars mostly conduct experiments based on basic models to prove the pharmacological effects of KXS and DZXW,but there is few research on the material basis of the efficacy and the mechanism of action,which needs further in-depth study.

关 键 词：开心散 定志小丸 化学成分 药理作用 差异 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]