中药单体干预博来霉素诱导肺纤维化动物模型相关调控机制研究进展  

Research progress on the regulatory mechanism of Chinese herbal monomer intervention in bleomycin-induced pulmonary fibrosis animal model

作　　者：石耀楠 王雪慧[2] SHI Yaonan;WANG Xuehui(Graduate College of Heilongjiang University of Chinese Medicine,Harbin 150040,China;First Affiliated Hospital Respiratory Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学研究生院,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院呼吸科,黑龙江哈尔滨150040

出　　处：《老年医学研究》2024年第4期64-68,共5页Geriatrics Research

基　　金：黑龙江省2023年青年岐黄学者培养项目.

摘　　要：肺纤维化病因不明,呈进行性加重,肺功能逐渐下降,且临床用于治疗药物较少。研究发现,中药单体在上皮细胞间质转化过程及其相关信号通路、激活细胞自噬、抑制巨噬细胞极化、抑制内质网应激等方面可发挥治疗博来霉素诱导的肺纤维化动物模型的作用。The cause of pulmonary fibrosis is unknown,progressive aggravation,gradual decline of lung function,and few clinical drugs for treatment.It was found that traditional Chinese medicine monomer can play a role in treating bleomycin-induced pulmonary fibrosis in animal model in the process of epithelial interstitial transformation and related sig‐naling pathway,activation of autophagy,inhibition of macrophage polarization and inhibition of endoplasmic reticulum stress.

关 键 词：肺纤维化 中药单体 调控机制 上皮细胞间质转化 细胞自噬 巨噬细胞极化 内质网应激 

分 类 号：R563[医药卫生—呼吸系统]