基于铁蛋白的递送系统在生物医学领域的研究进展  

Applications of ferritin-based delivery system in biomedical field

作　　者：成金妹 李嘉昕 段晓品 CHENG Jinmei;LI Jiaxin;DUAN Xiaopin(Cancer Research Institute,School of Basic Medical Sciences,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学基础医学院肿瘤研究所,广州510515

出　　处：《中国药科大学学报》2024年第4期530-537,共8页Journal of China Pharmaceutical University

摘　　要：铁蛋白普遍存在于各种生物体内,负责储存过量铁以维持体内铁平衡。由于铁蛋白具有固有靶向性、天然空腔结构、可逆性自组装、高生物相容性及易被修饰等天然优势,被认为是一种理想的递送系统,广泛应用于多个领域。本文重点综述铁蛋白的生物学特性、功能化修饰、载药策略以及在药物递送、生物催化、光动力治疗、医学成像以及疫苗研究等生物医学领域中的研究进展和应用前景,为基于铁蛋白的递送系统在生物医学领域中的相关研究提供借鉴。Ferritin is widely present in various organisms and is responsible for storing excess iron to maintain iron balance in vivo.Due to its inherent targeting ability,natural cavity structure,reversible self-assembly,high biocompatibility,and easy modification,ferritin is considered to be an ideal delivery system,which is widely used in many fields.This review summarizes the biological characteristics,functionalization,drug loading strategies,research progress and application prospects of ferritin-based nanocarrier systems in biomedical fields,such as drug delivery,biocatalysis,photodynamic therapy,medical imaging and vaccine research,aiming to provide some reference for related biomedical research based on ferritin delivery systems.

关 键 词：铁蛋白载体 功能化修饰 递送系统 生物医学应用 

分 类 号：R944[医药卫生—药剂学]