抗肿瘤术后植入式药物递送系统的研究进展与展望  

Research progress and prospects of implantable drug delivery systems for postoperative tumor therapy

作　　者：罗雪莲[1] 吴成声 查诚[1] 刘晟 LUO Xuelian;WU Chengsheng;ZHA Cheng;LIU Sheng(Department of Medicine,Tongling Polytechnic College,Tongling 244000;Tongling Municipal Hospital,Tongling 244000,China)

机构地区：[1]铜陵职业技术学院医学系,铜陵244000 [2]铜陵市立医院,铜陵244000

出　　处：《中国药科大学学报》2024年第4期538-547,共10页Journal of China Pharmaceutical University

基　　金：安徽省高校自然科学研究重点项目(No.KJ2021A138)。

摘　　要：植入式药物递送系统作为一种新兴治疗策略,显著增强了药物疗效,同时有效减轻了药物的不良反应,为肿瘤术后治疗提供了创新的解决方案。本文总结了术后肿瘤复发的关键诱因及相应的治疗策略,并全面探讨了近年来抗肿瘤术后植入式药物递送系统的研发进展,包括铸造型植入剂、静电纺丝植入剂、水凝胶植入剂等多种术后植入式药物递送系统。本综述全面总结了术后抗肿瘤植入式药物递送系统的应用前景,并展望了该领域未来的研发方向,希望这一领域的进一步发展能够促进肿瘤患者预后和生活质量的改善。Implantable drug delivery systems,as an emerging therapeutic approach,markedly amplify drug efficacy while mitigating drug toxicity and adverse effects,presenting an innovative avenue for postoperative tumor management.This review delineates pivotal triggers for postoperative tumor recurrence and their respective treatment modalities.Moreover,it comprehensively delves into recent strides in research and development of implantable drug delivery systems following anti-tumor surgery,encompassing implantable such drug delivery platforms as casting implants,electrospinning implants and hydrogel implants.The evolution of anti-tumor postoperative implantable drug delivery systems signifies a promising realm of research,poised to furnish more effective,tailored treatment modalities for cancer patients,heralding a beacon of fresh prospects in their rehabilitation.

关 键 词：癌症治疗 植入式药物递送系统 治疗策略 

分 类 号：R944[医药卫生—药剂学]