督灸对气道高反应患者的影响研究  

Study on Effect of Du-Moxibustion on Patients with Airway Hyperresponsiveness

作　　者：邹兰亭[1] 程喜荣 高雪琴 朱雅[1] 陈立夏 陈虹辛 薛媛[1] 金黑鹰[1] ZOU Lanting;CHENG Xirong;GAO Xueqin;ZHU Ya;CHEN Lixia;CHEN Hongxin;XUE Yuan;JINHeiying(The Second Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210017,China;Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学第二附属医院,江苏南京210017 [2]南京中医药大学,江苏南京210023

出　　处：《山东中医杂志》2024年第9期993-999,共7页Shandong Journal of Traditional Chinese Medicine

基　　金：江苏省中医药科技发展计划项目(编号:YB2020025);江苏省科技攻关计划(编号:BE2023786);第四批江苏省中医临床优秀人才研修项目(批文号:苏中医科教[2022]1号)。

摘　　要：目的:探讨督灸对气道高反应(AHR)患者炎症水平、肠道菌群及生活质量的影响。方法:采用自身前后对照试验,纳入30例AHR患者,采用督灸干预,观察患者炎症因子白细胞介素-4(IL-4)、白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)水平,肠道菌群结构、丰度、多样性、特征属,以及生活质量情况[采用圣乔治呼吸问卷(SGRQ)评估]。结果:接受督灸干预4周的AHR患者IL-4、IL-17、TNF-α水平、索伦森(Sorensen)指数、拟杆菌属丰度均有好转,差异均有统计学意义(P<0.05)。督灸干预前患者的关键细菌主要为脱硫弧菌、单形拟杆菌、革兰阳性菌、丝状霍尔德菌、格氏乳球菌、乳酸杆菌、甲酸芽殖菌、普氏菌、罗氏菌、乳酸乳球菌和S24_7菌,督灸干预后的关键细菌主要为多尔氏菌、伶俐瘤胃球菌、摩氏摩根菌、沙雷菌、殊异韦荣球菌、薰衣草梭菌、螺旋藻梭菌、阿尔登梭菌和松鼠葡萄球菌。督灸疗程结束后,患者SGRQ评分低于督灸干预前,差异具有统计学意义(P<0.05)。结论:督灸能改善AHR患者临床症状和生活质量,其作用机制可能与抑制炎症反应、调节肠道菌群有关。Objective:To investigate the effects of Du-moxibustion on inflammation level,intestinal flora and quality of life in patients with airway hyperresponsiveness(AHR).Methods:A self-controlled before and after trial was conducted in 30 patients with AHR,the intervention of Du-moxibustion was given.The levels of inflammatory factors[interleukin-4(IL-4),interleukin-17(IL-17),tumor necrosis factor-α(TNF-α)],intestinal flora structure,abundance,diversity,characteristics and quality of life[assessed by applying St.George’s Respiratory Questionnaire(SGRQ)]of the patients were observed.Results:The levels of IL-4,IL-17,TNF-α,Sorensen index,and abundances of Bacteroides in AHR patients receiving Du-moxibustion intervention for 4 weeks were improved,which were with statistically significant differences(P<0.05).The key bacteria of the patients before Du-moxibustion intervention were Vibrio desulphuricoides,Bacteroides monoformis,Gram-positive bacteria,Holderia filamenti,Lactococcus grigeri,Lactobacillus lactobacilli,Bacillus formicum,Prevotella,Roche,Lactococcus lactis and S24_7 bacteria.The key bacteria after Du-moxibustion intervention were Doleria,Rumenococcus limeniae,Rhizobacteria mosieri,Serratia,Veillonella variabilis,Clostridium lavandulae,Clostridium spiralis,Clostridium aldendii and Staphylococcus sciuris.The SGRQ scores of AHR patients after Du-moxibustion intervention were significantly lower than those before the intervention,and the difference was statistically significant(P<0.05).Conclusion:Du-moxibustion intervention can relieve the clinical symptoms and improve the quality of life in patients with AHR,and its mechanism may be related to inhibiting inflammation and regulating intestinal flora.

关 键 词：督灸 气道高反应 肠道菌群 炎症 生活质量 

分 类 号：R246.16[医药卫生—针灸推拿学]