Reactive oxygen species promote endurance exercise-induced adaptations in skeletal muscles  

作　　者：Scott K.Powers Zsolt Radak Li Li Ji Malcolm Jackson 

机构地区：[1]Department of Applied Physiology,University of Florida,Gainesville,FL 32608,USA [2]Research Institute of Sport Science,Hungarian University of Sport Science,Budapest 1123,Hungary [3]Department of Kinesiology,University of Minnesota,St.Paul,MN 55455,USA [4]Department of Musculoskeletal and Ageing Science,Institute of Life Course and Medical Sciences,University of Liverpool,Liverpool L78TX,UK

出　　处：《Journal of Sport and Health Science》2024年第6期780-792,共13页运动与健康科学（英文）

基　　金：supported by a grant from the National Institutes of Health(R21AR063956 to SKP)。

摘　　要：The discovery that contracting skeletal muscle generates reactive oxygen species(ROS)was first reported over 40 years ago.The prevailing view in the 1980s was that exercise-induced ROS production promotes oxidation of proteins and lipids resulting in muscle damage.However,a paradigm shift occurred in the 1990s as growing research revealed that ROS are signaling molecules,capable of activating transcriptional activators/coactivators and promoting exercise-induced muscle adaptation.Growing evidence supports the notion that reduction-oxidation(redox)signaling pathways play an important role in the muscle remodeling that occurs in response to endurance exercise training.This review examines the specific role that redox signaling plays in this endurance exercise-induced skeletal muscle adaptation.We begin with a discussion of the primary sites of ROS production in contracting muscle fibers followed by a summary of the antioxidant enzymes involved in the regulation of ROS levels in the cell.We then discuss which redox-sensitive signaling pathways promote endurance exercise-induced muscle adaptation and debate the strength of the evidence supporting the notion that redox signaling plays an essential role in muscle adaptation to endurance exercise training.In hopes of stimulating future research,we highlight several important unanswered questions in this field.

关 键 词：ANTIOXIDANTS Mitochondrial biogenesis RADICALS Redox signaling 

分 类 号：G804.2[文化科学—运动人体科学]