Co(Ⅱ)2,2',4,4'-四羟基二苯甲酮-乙二胺席夫碱配合物的合成及其催化硫醚不对称氧化的探究  

Synthesis of Co(Ⅱ)2,2',4,4'-Tetrahydroxy Benzophenone Ethylenediamine Schiff Base Complexes and Investigation of Their Catalytic Asymmetric Oxidation of Thioethers

作　　者：唐洁 覃昌铭 TANG Jie;QIN Changming

机构地区：[1]广西卫生职业技术学院,广西南宁530023

出　　处：《化工设计通讯》2024年第8期23-25,共3页Chemical Engineering Design Communications

摘　　要：手性席夫碱(Schiff base)配合物催化的硫醚不对称氧化反应是现有最有效的方法之一。利用2,2’,4,4’-四羟基二苯甲酮-乙二胺反应合成席夫碱配体,水热法合成配合物(CoL_(1))。考察了在牛血清白蛋白存在下CoL_(1)催化硫醚不对称氧化反应的催化活性,并考察了缓冲溶液pH、氧化剂浓度、底物浓度、氧化剂种类、反应温度等反应条件对催化活性的影响。通过单因素实验探究实验,得到了CoL_(1)催化苯基甲基硫醚不对称氧化反应的最优反应条件,获得了79.72%的转化率和99.13%的化学选择性,但对映体选择性较低(7.91%)。The asymmetric oxidation of thioethers catalyzed by chiral schiff base complexes is one of the most effective methods currently available.The article utilizes the reaction of 2,2',4,4'-tetrahydroxybenzophenone ethylenediamine to synthesize Schiff base ligands,and hydrothermal synthesis of complex(CoL_(1)).The catalytic activity of this complex as a catalyst for the asymmetric oxidation of thioethers in the presence of bovine serum albumin was investigated.And the effects of reaction conditions such as buffer solution pH,oxidant concentration,substrate concentration,oxidant type,and reaction temperature on catalytic activity were investigated.The optimal reaction conditions for the asymmetric oxidation of phenyl methyl sulfide catalyzed by coL1 were obtained through single factor experiments.A conversion rate of 79.72%and a chemical selectivity of 99.13%were achieved,but the enantioselectivity was low(7.91%).

关 键 词：硫醚不对称氧化 席夫碱配合物 手性亚砜 牛血清白蛋白 

分 类 号：O641.4[理学—物理化学]