自然杀伤(NK)细胞应对结核分枝杆菌感染的研究进展  

Advances in the study of natural killer(NK)cells’response to Mycobacterium tuberculosis infection

作　　者：任芹 杨国平 REN Qin;YANG Guoping(Department of Medical Microbiology and Immunology,School of Basic Medicine,Dali University,Dali 671000,China)

机构地区：[1]大理大学基础医学院医学微生物学及免疫学教研室,云南大理671000

出　　处：《细胞与分子免疫学杂志》2024年第7期660-665,共6页Chinese Journal of Cellular and Molecular Immunology

基　　金：云南省地方本科高校联合专项面上项目(2017FH001-085);大理大学高层次人才资助项目(KYBS201708);大理大学临床分子免疫学创新团队(ZKLX2019105)。

摘　　要：结核病(TB)是由结核分枝杆菌(MTB)感染引起的严重威胁人类健康的慢性传染病。自然杀伤(NK)细胞作为先天免疫的重要组成部分,在应对MTB感染时,NK细胞可分化出不同亚群,表现出受体和功能的多样性;并通过分泌细胞因子,串联其他免疫细胞发挥对MTB的抗感染作用,从而增强机体的抗MTB免疫应答反应。Tuberculosis(TB)is a chronic infectious disease caused by Mycobacterium tuberculosis(MTB)infection and poses a serious threat to human health.Natural killer(NK)cells,an important component of innate immunity,can differentiate into various subpopulations in response to MTB infection,showing a diversity of receptors and functions.They engage in crosstalk with other immune cells by secreting cytokines,thereby exerting anti-infective actions against MTB infection and enhancing the body’s immune response to the infection.

关 键 词：自然杀伤(NK)细胞 感染与免疫 NK细胞表型与受体 抗结核免疫 综述 

分 类 号：R378.911[医药卫生—病原生物学] G353.11[医药卫生—基础医学]