不同程度儿童1型糖尿病酮症酸中毒与血清hs-CRP、IL-10、IgE、NLR水平的相关性分析  

Correlation Analysis of Different Degress of Children with Type 1 Diabetes Ketoacidosis and Serum hs-CRP,IL-10,IgE,NLR Levels

作　　者：孙慧芹[1] 宋振香 刘海婷[1] SUN Huiqin;SONG Zhenxiang;LIU Haiting(Department of Laboratory,the New Campus of Zibo Maternal and Child Health Hospital,Zibo 255000,Shandong,China)

机构地区：[1]淄博市妇幼保健院新院区检验科,山东淄博255000

出　　处：《糖尿病新世界》2024年第10期48-50,54,共4页Diabetes New World

摘　　要：目的探讨不同程度儿童1型糖尿病酮症酸中毒血清高敏-C反应蛋白(high-sensitivity C-reactive pro-tein,hs-CRP)、白细胞介素-10(interleukin-10,IL-10)、免疫球蛋白E(serum immunoglobulin E,IgE)、中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)水平的相关性。方法回顾性选取2022年1月—2023年5月淄博市妇幼保健院收治的52例儿童1型糖尿病酮症酸中毒患儿的临床资料,进行血清hs-CRP、IL-10、IgE、NLR检测,对检测结果进行相关性分析。结果重度酮症酸中毒患儿血清hs-CRP、IL-10高于轻度、中度患儿,IgE水平低于轻度、中度患儿,差异有统计学意义(P均<0.05)。儿童1型糖尿病酮症酸中毒的严重程度与血清hs-CRP、IL-10呈正相关,与IgE呈负相关(P均<0.05);与NLR无相关性(P>0.05)。结论对于儿童1型糖尿病酮症酸中毒的诊断中,血清hs-CRP、IL-10、IgE均发挥重要作用,NLR对于细菌感染的判断具有积极作用,可更好的对疾病进行诊断,同时监控疾病进展,是诊断和评估病情变化的重要指标。Objective To investigate the correlation of different degress of children with type 1 diabetes ketoacidosis and levels of serum high-sensitivity C-reactive protein(hs-CRP),interleukin-10(IL-10),serum immunoglobulin E(IgE),and neutrophil to lymphocyte ratio(NLR).Methods The clinical data of 52 children with type 1 diabetic keto-acidosis admitted to Zibo Maternal and Child Health Hospital from January 2022 to May 2023 were retrospectively se-lected.Serum hs-CRP,IL-10,IgE and NLR were detected,and the test results were correlation analyzed.Results The levels of serum hs-CRP and IL-10 in children with severe ketoacidosis were higher than those in children with mild and moderate ketoacidosis,and the level of IgE was lower than that in children with mild and moderate ketoaci-dosis,and the differences were statistically significant(all P<0.05).The severity of ketoacidosis in children with type 1 diabetes mellitus was positively correlated with serum hs-CRP and IL-10,and negatively correlated with IgE(all P<0.05).There was no correlation with NLR(P>0.05).Conclusion Serum hs-CRP,IL-10 and IgE play an important role in the diagnosis of type 1 diabetic ketoacidosis in children.NLR has a positive effect on the judgment of bacterial infection,which can better diagnose the disease and monitor the progress of the disease.It is an important indicator for the diagnosis and evaluation of disease changes.

关 键 词：儿童1型糖尿病酮症酸中毒 血清高敏-C反应蛋白 白细胞介素-10 免疫球蛋白E 中性粒细胞与淋巴细胞比值 

分 类 号：R446.1[医药卫生—诊断学]