妊娠期糖尿病治疗方案中短效及长效胰岛素联用的效果分析  

Effect of Combined Use of Short-term and Long-term Insulin in the Treatment of Gestational Diabetes Mellitus

作　　者：韩宇南 李琳[1] 肖玉欣 HAN Yunan;LI Lin;XIAO Yuxin(Department of Endocrinology,the First Affiliated Hospital of Yangtze University,Jingzhou 434000,Hubei,China;School of Medicine,University of Electronic Science and Technology,Chengdu 610054,Sichuan,China)

机构地区：[1]长江大学第一附属医院内分泌科,湖北荆州434000 [2]电子科技大学医学院,四川成都610054

出　　处：《糖尿病新世界》2024年第10期62-64,83,共4页Diabetes New World

摘　　要：目的分析妊娠期糖尿病治疗方案中短效及长效胰岛素联用的效果。方法选取2024年1—3月在长江大学附属第一医院治疗的100例妊娠期糖尿病患者为研究对象,根据不同治疗方案分为观察组(50例)和对照组(50例),对照组采用短效胰岛素治疗,观察组采用短效、长效胰岛素联用治疗,对比两组血糖水平[空腹血糖(fasting plasma glucose,FPG)、糖化血红蛋白(glycated hemoglobin A1c,HbA1c)、胰岛β细胞功能指数(ho-meostasis model assessment isletβcell function,hOMA-β)]及剖宫产率、不良妊娠结局(产后出血、新生儿窒息、胎儿窘迫、早产)发生率。结果治疗前,两组FPG、HbA1c、HOMA-IR水平相比,差异无统计学意义(P均>0.05);治疗后,两组FPG、HbA1c、HOMA-β均显著改善,且观察组优于对照组,差异有统计学意义(P均<0.05)。观察组不良妊娠结局率与剖宫率均低于对照组,差异有统计学意义(P均<0.05)。结论妊娠期糖尿病治疗方案中短效及长效胰岛素联用具有良好的疗效,更有利于促进血糖水平及胰岛β细胞功能指数改善,降低不良妊娠结局率。Objective To analyze the effect of short-acting and long-acting insulin in the treatment of gestational dia-betes mellitus.Methods A total of 100 patients with gestational diabetes mellitus who were treated in the First Affili-ated Hospital of Yangtze University from January to March 2024 were selected as the research objects.According to the different treatment method,they were divided into observation group(50 cases)and control group(50 cases).The control group was treated with short-acting insulin,and the observation group was treated with short-acting and long-acting insulin.The blood glucose levels[fasting plasma glucose(FPG),glycated hemoglobin A1c(HbA1c),homeosta-sis model assessment isletβcell function(HOMA-IR),the rate of cesarean section and adverse pregnancy outcome(Postpartum hemorrhage,neonatal asphyxia,fetal distress,preterm)of the two groups were compared.Results Before treatment,there were no statistically significant differences in the levels of FPG,HbA1c and HOMA-βbetween the two groups(all P>0.05).After treatment,FPG,HbA1c and HOMA-βin the two groups were significantly improved,and the observation group was better than the control group,and the differences were statistically significant(all P<0.05).The adverse pregnancy outcome rate and cesarean section rate of the observation group were lower than those of the control group,and the differences were statistically significant(both P<0.05).Conclusion The combination of short-term and long-term insulin in the treatment of gestational diabetes mellitus has a good effect,which is more con-ducive to promoting the improvement of blood glucose level and HOMA-β,and reducing the rate of adverse preg-nancy outcomes.

关 键 词：妊娠期糖尿病 短效胰岛素 不良妊娠结局 剖宫产 长效胰岛素 

分 类 号：R714[医药卫生—妇产科学]