阿芬太尼与舒芬太尼辅助丙泊酚在女性患者无痛胃镜检查中的效果比较  

Comparison of the Efficacy of Propofol Assisted by Fentanyl and Sufent⁃anil in Painless Gastroscopy in Female Patients

作　　者：陆斌 LU Bin(Department of Anesthesiology,Tongzhou District People′s Hospital,Nantong 226300,Jiangsu,China)

机构地区：[1]南通市通州区人民医院麻醉科,江苏南通226300

出　　处：《系统医学》2024年第13期7-10,22,共5页Systems Medicine

基　　金：南通市卫健委科研课题(MS2022113)。

摘　　要：目的比较阿芬太尼联合丙泊酚与舒芬太尼联合丙泊酚在女性患者无痛胃镜麻醉中的效果和安全性。方法非随机选取2023年1月—2024年3月南通市通州区人民医院接受无痛胃镜检查的180名妇女为研究对象。按麻醉方式不同分为观察组(阿芬太尼+丙泊酚)和对照组(舒芬太尼+丙泊酚),各90例。比较两组患者的麻醉效果、不同时间点的各项生命体征以及术后不良反应发生情况。结果观察组首次麻醉诱导成功率为100.00%,对照组为94.44%,两组比较,差异无统计学意义(χ^(2)=3.291,P>0.05)。两组入睡、苏醒以及肌力恢复时间,丙泊酚用量,躁动整体情况比较,差异无统计学意义(P均>0.05)。两组各时间点时的心率、血氧饱和度,T0和T3时间点的平均动脉压比较,差异无统计学意义(P均>0.05);但T1和T2时间点,观察组平均动脉压低于对照组,差异有统计学意义(P均<0.05)。两组呼吸抑制、心动过缓、呛咳发生率比较,差异无统计学意义(P均>0.05);观察组恶心呕吐和低血压发生率均低于对照组,差异有统计学意义(P均<0.05)。结论无痛胃镜麻醉中,与舒芬太尼比较,阿芬太尼联合丙泊酚静脉麻醉循环的抑制作用更小,其术后发生低血压和恶心呕吐的概率也更低,综合安全性较高。Objective To compare the efficacy and safety of fentanyl combined with propofol and sufentanil combined with propofol in painless gastroscopy anesthesia for female patients.Methods A total of 180 women who underwent painless gastroscopy examination at Tongzhou District People's Hospital in Nantong City from January 2023 to March 2024 were non-randomly selected as the study objects.They were divided into an observation group(fentanyl+propo-fol)and a control group(sufentanil+propofol)according to different anesthesia method,with 90 cases in each group.The anesthesia effects,various vital signs at different time points,and incidence of postoperative adverse reactions be-tween two groups of patients were compared.Results The success rate of first anesthesia induction in the observation group was 100.00%,while in the control group was 94.44%,there was no statistically significant difference between the two groups(χ^(2)=3.291,P>0.05).There was no statistically significant difference in the time to fall asleep,wake up,and muscle strength recovery,propofol dosage,and overall restlessness between the two groups(all P>0.05).There was no statistically significant difference in heart rate,blood oxygen saturation,and mean arterial pressure at T0 and T3 time points between the two groups(all P>0.05).However,at time points T1 and T2,the average arterial pressure in the observation group was lower than that in the control group,and the differences were statistically significant(both P<0.05).There was no statistically significant difference in the incidence of respiratory depression,bradycardia,and choking cough between the two groups(all P>0.05).The incidence of nausea and vomiting,hypotension in the ob-servation group were lower than that in the control group,and the differences were statistically significant(both P<0.05).Conclusion In painless gastroscopy anesthesia,compared with sufentanil,the inhibitory effect of fentanyl com-bined with propofol intravenous anesthesia on circulation is less,and the probability of postoperat

关 键 词：阿芬太尼 舒芬太尼 丙泊酚 无痛胃镜 

分 类 号：R4[医药卫生—临床医学]