不同剂量左甲状腺素治疗妊娠合并甲状腺功能减退症的临床获益分析  

Clinical Benefit Analysis of Different Doses of Levothyroxine in the Treat⁃ment of Pregnancy with Hypothyroidism

作　　者：李艳春 郑玉玲 LI Yanchun;ZHENG Yuling(Department of Obstetrics,Wenshang County Maternal and Child Health and Family Planning Service Center,Jining 272500,Shandong,China)

机构地区：[1]汶上县妇幼保健计划生育服务中心产科,山东济宁272500

出　　处：《系统医学》2024年第13期27-30,共4页Systems Medicine

摘　　要：目的分析应用不同剂量左甲状腺素治疗妊娠合并甲状腺功能减退症孕妇的临床获益。方法非随机选取2020年1月—2022年6月汶上县妇幼保健计划生育服务中心收治的96例妊娠期孕妇(均伴有甲状腺功能减退症)为研究对象,依治疗方案不同分为对照组(48例,采用低剂量左甲状腺素治疗)、观察组(48例,采用高剂量左甲状腺素治疗)。比较两组的治疗效果。结果观察组的总有效率为95.83%,高于对照组的83.33%,差异有统计学意义(χ^(2)=4.019,P<0.05)。观察组的甲状腺功能和血脂代谢水平均优于对照组,差异有统计学意义(P均<0.05)。观察组新生儿出生6个月后的智能发育指数、运动发育指数评分较对照组更高,差异有统计学意义(P均<0.05)。观察组的不良反应总发生率高于对照组,差异有统计学意义(P<0.05)。结论应用左甲状腺素治疗妊娠合并甲状腺功能减退症孕妇时,相较于低剂量,应用高剂量的效果更显著,能够有效改善孕妇甲状腺功能,调节血脂水平,促进子代发育,但存在一定的安全性问题,临床需重视并密切关注治疗过程。Objective To analyze the clinical benefit of different doses of levothyroxine in the treatment of pregnant women with hypothyroidism.Methods A total of 96 pregnant women(all with hypothyroidism)admitted to Wenshang County Maternal and Child Health Care Family Planning Service Center from January 2020 to June 2022 were non-randomly selected as the study objects,and were divided into control group(48 cases,treated with low-dose levothy-roxine)and observation group(48 cases,treated with high-dose levothyroxine)according to different treatment meth-ods.The therapeutic effect of the two groups was compared.Results The total effective rate of the observation group was 95.83%,higher than that of the control group(83.33%),the difference was statistically significant(χ^(2)=4.019,P<0.05).The thyroid function and lipid metabolism in the observation group were better than those in the control group,and the differences were statistically significant(both P<0.05).The scores of intelligence development index and mo-tor development index in the observation group were higher than those in the control group at 6 months after birth,and the differences were statistically significant(both P<0.05).The total incidence of adverse reactions in observation group was higher than that in control group,and the difference was statistically significant(P<0.05).Conclusion Com-pared with low dose,high dose of levothyroxine is more effective in the treatment of pregnant women with hypothyroid-ism,which can effectively improve the thyroid function of pregnant women,regulate the level of blood lipids and pro-mote the development of offspring.However,there are certain safety problems,and clinical attention and close atten-tion should be paid to the treatment process.

关 键 词：妊娠 甲状腺功能减退症 左甲状腺素 甲状腺功能 血脂 

分 类 号：R714.256[医药卫生—妇产科学]