阿托伐他汀和瑞舒伐他汀强化治疗方案控制脑动脉粥样硬化进展的疗效及安全性  

Efficacy and Safety of Intensive Treatment of Atorvastatin and Rosuvas⁃tatin in Controlling Progression of Cerebral Atherosclerosis

作　　者：袁凯凯 缪建华 缪怡 YUAN Kaikai;MIAO Jianhua;MIAO Yi(Department of Cardiology,Tongzhou District Traditional Chinese Medicine Hospital,Nantong 226300,Jiangsu,China;Department of Geriatrics,Nantong University Affiliated Hospital,Nantong 226001,Jiangsu,China)

机构地区：[1]南通市通州区中医院心内科,江苏南通226300 [2]南通大学附属医院老年科,江苏南通226001

出　　处：《系统医学》2024年第13期109-111,115,共4页Systems Medicine

摘　　要：目的探讨阿托伐他汀和瑞舒伐他汀强化治疗方案控制脑动脉粥样硬化进展的疗效及安全性。方法非随机选取2021年1月—2023年1月南通市通州区中医院收治的160例动脉粥样硬化性脑梗死患者,根据不同用药分为研究组和对照组,各80例。研究组采用瑞舒伐他汀强化治疗,对照组采用阿托伐他汀强化治疗,对两组的治疗效果进行比较。结果研究组临床总有效率为97.50%,优于对照组的88.75%,差异有统计学意义(χ^(2)=4.783,P<0.05)。治疗后,研究组颈动脉粥样硬化斑块指标、血脂指标水平优于对照组,差异有统计学意义(P均<0.05)。研究组不良反应发生率更低,但两组比较,差异无统计学意义(P>0.05)。结论瑞舒伐他汀强化治疗对于控制脑动脉粥样硬化进展的效果较为明显,可以改善患者的血脂水平,稳定颈动脉粥样硬化斑块,不良反应少。Objective To explore the efficacy and safety of atorvastatin and rosuvastatin to control the progression of cerebral atherosclerosis.Methods A total of 160 patients with atherosclerotic cerebral infarction admitted to Tongzhou District Traditional Chinese Medicine Hospital in Nantong from January 2021 to January 2023 were non-randomly se-lected and divided into the study group and the control group according to the different medications used,with 80 cases in each group.The study group was treated with intensive therapy of rosuvastatin and the control group was treated with intensive therapy of Atorvastatin,and the therapeutic effects of the two groups were compared.Results The total clinical effectiveness rate of the study group was 97.50%,which was better than 88.75%of the control group,and the difference was statistically significant(χ^(2)=4.783,P<0.05).After treatment,the levels of carotid atherosclerotic plaque indexes and lipid indexes in the study group were better than those in the control group,and the differences were statistically significant(all P<0.05).The incidence of adverse reactions was lower in the study group,but the dif-ference was not statistically significant(P>0.05).Conclusion Intensive therapy with Rosuvastatin is more effective in controlling the progression of cerebral atherosclerosis,improving patients'lipid levels and stabilizing carotid athero-sclerotic plaques,with fewer adverse effects.

关 键 词：阿托伐他汀 瑞舒伐他汀 脑动脉粥样硬化进展 斑块稳定性 

分 类 号：R541.4[医药卫生—心血管疾病]