纤维支气管镜下盐酸氨溴索灌洗对重症肺炎患儿心肌酶谱及CRP、PCT水平的影响  

The Effect of Ambroxol Hydrochloride Lavage under Fiberoptic Bronchos⁃copy on Myocardial Enzyme Spectrum,CRP,and PCT Levels in Children with Severe Pneumonia

作　　者：李伟文 LI Weiwen(General Pediatrics Department,Yunfu Maternal and Child Health Hospital,Yunfu 527300,Guangdong,China)

机构地区：[1]云浮市妇幼保健院普儿科,广东云浮527300

出　　处：《系统医学》2024年第13期145-148,共4页Systems Medicine

摘　　要：目的探究纤维支气管镜下盐酸氨溴索灌洗对重症肺炎患儿心肌酶谱及CRP、PCT水平的影响。方法非随机选取云浮市妇幼保健院于2021年5月—2023年12月收治的50例重症肺炎患儿为研究对象,根据不同治疗方法分为常规组与观察组,各25例。两组均予以重症肺炎常规治疗,观察组额外予以纤维支气管镜下盐酸氨溴索灌洗,常规组灌洗药物为生理盐水。分别于治疗前、治疗7 d后测定患儿心肌酶谱[肌酸激酶(Creatine Kinase,CK)、肌酸激酶同工酶(Creatine Kinase Isoenzymes,CK-MB)、天门冬氨酸转氨酶(Aspartate Aminotransferase,AST)水平]及C反应蛋白(C-Reactive Protein,CRP)、降钙素原(Procalcitonin,PCT)水平,并记录症状改善情况。结果观察组CK(32.72±8.51)U/L、AST(31.49±4.71)U/L、CK-MB(32.35.±6.36)U/L、PCT(3.97±0.82)µg/L、CRP(15.44±4.61)mg/L均低于常规组,差异有统计学意义(t=3.142、4.946、4.089、4.945、4.856,P均<0.05);观察组肺部湿啰音消失时间、退热时间、每日咳嗽次数均少于常规组,差异有统计学意义(P均<0.05)。结论辅以纤维支气管镜下盐酸氨溴索灌洗治疗重症肺炎患儿可以降低其心肌酶谱、C反应蛋白、降钙素水平,加快患儿的康复进程。Objective To investigate the effects of ambroxol hydrochloride lavage under fiberoptic bronchoscopy on myocardial enzyme spectrum,CRP,and PCT levels in children with severe pneumonia.Methods Fifty children with severe pneumonia admitted to Yunfu Maternal and Child Health Hospital from May 2021 to December 2023 were non randomly selected as the study objects,and were divided into routine group and observation group according to differ-ent treatment modalities,with 25 cases in each group.Both groups were given routine treatment for severe pneumonia.The observation group was given additional irrigation with ambroxol hydrochloride under bronchoscope,and the con-ventional group was given irrigation with normal saline.Respectively before and after 7 d treatment determination with myocardial enzyme spectrum[creatine kinase(CK),creatine kinase isoenzyme(CK-MB),aspartate aminotransferase(AST)]and c-reactive protein(CRP),procalcitonin(PCT),and record the symptoms improve the situation.Results CK(32.72±8.51)U/L,AST(31.49±4.71)U/L,CK-MB(32.35.±6.36)U/L,PCT(3.97±0.82)μg/L,CRP(15.44±4.61)mg/L in observation group were lower than those in conventional group,the differences were statistically significant(t=3.142,4.946,4.089,4.945,4.856,all P<0.05).The disappearance time of lung moist rales,fever remission time and daily cough times in observation group were less than those in conventional group,and the differences were statisti-cally significant(all P<0.05).Conclusion The treatment of children with severe pneumonia with ambroxol hydrochlo-ride under bronchoscopy can reduce the levels of myocardial enzyme spectrum,C-reactive protein and calcitonin,and accelerate the recovery process of children.

关 键 词：纤维支气管镜 盐酸氨溴索 重症肺炎 心肌酶谱 炎症因子 

分 类 号：R725.6[医药卫生—儿科]