分析甲氨蝶呤以不同给药方法治疗未破裂型异位妊娠的疗效  

Observation of the Therapeutic Effect of Different Administration Meth⁃ods of Methotrexate on Unruptured Ectopic Pregnancy

作　　者：黄锦 杨萍 HUANG Jin;YANG Ping(Department of Gynecology,Huaxi District People′s Hospital,Guiyang 550025,Guizhou,China)

机构地区：[1]贵州省贵阳市花溪区人民医院妇科,贵州贵阳550025

出　　处：《系统医学》2024年第13期149-151,155,共4页Systems Medicine

摘　　要：目的全面评估将甲氨蝶呤(Methotrexate,MTX)以不同给药方式用于未破裂型异位妊娠的治疗效果。方法非随机选取贵州省贵阳市花溪区人民医院2019年7月—2022年7月期间收治的未破裂型异位妊娠保守治疗100例患者作为研究对象。通过MTX给药方法的不同,将其分成A组(单次肌注MTX,57例)、B组(单孔腹腔镜下患处注射MTX,43例)。对两组的治疗相关指标[人绒毛膜促性腺激素(Human Chorionic Gonado-trophin,β-HCG)转阴时间、平均住院时间、治疗2周后的妊娠包块大小]和不良反应发生情况进行观察比较。结果A组的β-HCG转阴时间、平均住院时间均较B组更短,A组治疗2周后的妊娠包块大小较B组更小,差异有统计学意义(P均<0.05);A组的不良反应发生率为7.02%,低于B组的23.26%,差异有统计学意义(χ^(2)=5.368,P<0.05)。结论在未破裂型异位妊娠中,采用MTX治疗具有十分积极的效果,不同给药方式其治疗效果也不尽相同,其中以单次肌注MTX的效果更佳,不良反应较少,可作为患者的首选治疗方式,但仍应结合患者实际情况综合考虑最佳治疗方式。Objective To comprehensively evaluate of the therapeutic efficacy of methotrexate in different modes of administration for unruptured ectopic pregnancy.Methods 100 patients with unruptured ectopic pregnancy who under-went conservative treatment at Huaxi District People's Hospital in Guiyang City,Guizhou Province from July 2019 to July 2022 were non-randomly selected as the study subjects.According to the different methods of MTX administra-tion,they were divided into Group A(single intramuscular injection of MTX,57 cases)and Group B(single port lapa-roscopic injection of MTX at the affected area,43 cases).Treatment related indicators(human chorionic gonadotropin,β-Compare the time of HCG negative conversion,average hospital stay,and gestational mass size after 2 weeks of treatment)and the occurrence of adverse reactions between the two groups were observed and compared.Results Group A'sβ-The time for HCG to turn negative and the average length of hospital stay were shorter than those in Group B,the gestational mass size after 2 weeks of treatment in Group A was smaller than that in Group B,the differ-ence was statistically significant(all P<0.05).The incidence of adverse reactions in Group A was 7.02%,which was lower than 23.26%of group B,the difference was statistically significant(χ^(2)=5.368,P<0.05).Conclusion MTX treat-ment has a very positive effect in unruptured ectopic pregnancy,and the treatment effect varies with different adminis-tration methods.Among them,a single intramuscular injection of MTX is more effective with fewer adverse reactions,and can be used as the preferred treatment for patients.It has certain promotional value,but the best treatment method should still be considered comprehensively based on the actual situation of patients.

关 键 词：甲氨蝶呤 不同给药方法 未破裂型 异位妊娠 

分 类 号：R711[医药卫生—妇产科学]