N6-甲基腺苷在疾病中的研究进展  

Research progress of N6-methyladenosine in diseases

作　　者：潘旺 周爱华[1] PAN Wang;ZHOU Aihua(School of Pharmacy,Jiangsu University,Zhenjiang 212013,Jiangsu Province,China)

机构地区：[1]江苏大学药学院,江苏镇江212013

出　　处：《中国药师》2024年第8期1436-1444,共9页China Pharmacist

摘　　要：N6-甲基腺苷(m6A)修饰是由甲基化酶和去甲基化酶调节,导致一个动态和可逆的过程。m6A水平的变化涉及广泛的细胞过程,包括核RNA输出、mRNA代谢、蛋白质翻译和RNA剪接,与各种疾病有很强的相关性。本文旨在归纳和总结mRNA中m6A表达水平的变化在常见三类疾病中的作用和机制,以及基于m6A在mRNA中水平变化作为药物干预靶点的研究趋势。N6-methyladenosine modification is regulated by methylase and demethylase,resulting in a dynamic and reversible process.Changes in m6A levels are involved in a wide range of cellular processes,including nuclear RNA output,mRNA metabolism,protein translation,and RNA splicing,and have strong associations with various diseases.The purpose of this paper is to generalize and summarize the role and mechanism of the change of m6A expression level in mRNA in three common diseases,as well as the research trend based on the change of m6A level in mRNA as a drug intervention target.

关 键 词：N6-甲基腺苷 甲基化酶 去甲基化酶 细胞过程 肺癌 肺纤维化 肾癌 急性肾损伤 哮喘 阿尔兹海默症 研究进展 

分 类 号：R91[医药卫生—药学]