爵床化学成分、药理作用与临床应用的研究进展及其质量标志物预测分析  

Progress in the study of chemical composition,pharmacological action and clinical application of Justicia procumbens and predictive analysis of its quality markers

作　　者：曾景 刘傲蕾 薛永琪 吴和珍 杨艳芳 刘博 艾中柱 ZENG Jing;LIU Aolei;XUE Yongqi;WU Hezhen;YANG Yanfang;LIU Bo;AI Zhongzhu(Faculty of Pharmacy,Hubei University of Chinese Medicine,Wuhan 430065,China;Hubei Shizhen Laboratory,Wuhan 430065,China;Modern Engineering Research Center of Traditional Chinese Medicine and Ethnic Medicine of Hubei Province,Wuhan 430065,China;Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province,Wuhan 430061,China)

机构地区：[1]湖北中医药大学药学院,武汉430065 [2]湖北时珍实验室,武汉430065 [3]现代中药与民族药湖北省工程研究中心,武汉430065 [4]中药资源与中药化学湖北省重点实验室,武汉430061

出　　处：《中国药师》2024年第8期1445-1458,共14页China Pharmacist

基　　金：湖北省自然科学基金项目(2022CFB849)。

摘　　要：爵床主要含有木脂素、黄酮、生物碱等类型的化学成分,临床上常用于辅助治疗疟疾、热病、肺热咳嗽、毒蛇咬伤等疾病。现代药理研究表明其具有抗血小板聚集、镇痛、抗肿瘤和抗炎等多种药理作用。本综述对爵床的本草考证进行了更具体的归纳,并结合国内外研究对爵床的化学成分、药理作用以及临床应用进行了总结,基于“五原则”及网络药理学、传统药性对爵床的质量标志物(Q-Marker)进行预测分析。初步预测6′-羟基爵床脂定A、6'-羟基爵床脂定B、6'-羟基爵床脂定C、爵床脂定B、金不换甲醚、山奈酚等成分可作为爵床的Q-Marker,以期为更好地开发和利用爵床属植物资源提供借鉴。The chemical constituents of Justicia procumbens are mainly lignans,flavonoids,alkaloids,etc.It is commonly used in clinical practice as an adjunctive treatment for malaria,fevers,coughs of pulmonary fever,poisonous snake bites and other diseases.Modern pharmacological studies have shown that Justicia procumbens has anti-platelet aggregation,analgesic,anti-tumor and anti-inflammatory effects.In this review,the herbal evidence of Justicia procumbens was summarised in more detail,and the chemical composition,the pharmacological effects and clinical applications of Justicia procumbens were summarised in combination with domestic and international studies,and the quality marker(Q-Marker)of Justicia procumbens was predicted and analyzed on the basis of the Five Principles,network pharmacology,and traditional medicinal properties.The preliminary predictions of 6'-hydroxy justicidin A,6'-hydroxy justicidin B,6'-hydroxy justicidin C,justicidin B,Chinensinaphthol methyl ether,and kaempferol were used as the Q-Markers of Justicia procumbens with a view to provide a reference for the better development and utilisation of Justicia resources.

关 键 词：爵床 化学成分 药理作用 临床应用 质量标志物 6′-羟基爵床脂定A 6'-羟基爵床脂定B 6'-羟基爵床脂定C 爵床脂定B 金不换甲醚 山奈酚 研究进展 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]