基于子午流注理论择时姜泥督灸对早中期强直性脊柱炎(肝肾亏虚证)患者脊柱功能及CS、IDH、α-KGDHC水平的影响  

Based on the Meridian Flow Theory,the Influence of Ginger Mud-tut Moxibustion on Spinal Function and the Levels of CS,IDH andα-KGDHC in Patients with Early and Middle Ankylosing Spondylitis(Deficiency of Liver and Kidney)

作　　者：姚亚利 杜明瑞[1] 王德贞 王露[1] YAO Yali;DU Mingrui;WANG Dezhen(Department of Rheumatology and Immunology,The First Affiliated Hospital of Henan,University of Traditional Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院风湿免疫科,河南郑州450000

出　　处：《航空航天医学杂志》2024年第8期983-986,共4页Journal of Aerospace medicine

基　　金：河南省中医药传承与创新人才工程(仲景工程)中医药学科拔尖人才(项目号:CZ0237-15)。

摘　　要：目的探讨早中期强直性脊柱炎(肝肾亏虚证)患者应用基于子午流注理论择时循经姜泥督灸后脊柱功能、炎症因子、三羧酸循环(TCA)关键酶水平的变化。方法选取我科2020年11月至2022年09月期间124例早中期强直性脊柱炎(肝肾亏虚证)患者作为研究对象,用机械抽样法将其分为基础组62例,观察组62例,基础组62例给予甲氨蝶呤+洛索洛芬钠等基础干预,观察组62例在此基础上增加基于子午流注理论择时循经姜泥督灸,对比两组患者临床改善效果、脊柱功能、血清炎症因子水平、三羧酸循环(TCA)关键酶水平。结果观察组患者的病情活动指数(BASDAI)、功能指数(BASFI)评分以及指地距、枕墙距均比基础组患者低(P<0.05);胸廓呼吸活动度两组间差异无统计学意义(P>0.05);干预后两组患者炎症指标C-反应蛋白(CRP)等水平均比干预前低(P<0.05),观察组患者干预后各炎症指标水平均比基础组低(P<0.05);两组患者干预后α-酮戊二酸脱氢酶(α-KGDHC)水平较干预前高,柠檬酸合成酶(CS)、异柠檬酸脱氢酶(IDH)水平较干预前低(P<0.05);观察组患者干预后α-KGDHC、CS、IDH各TCA关键酶水平变化幅度比基础组大(P<0.05)。结论基于子午流注理论择时姜泥督灸可以有效改善早中期强直性脊柱炎(肝肾亏虚证)患者的临床症状与体征,促进脊柱功能恢复,降低炎症反应水平,临床效果佳,其机制可能与调节TCA关键酶表达有关。Objective To investigate the changes of spinal function,inflammatory factors and TCA key enzyme levels in patients with early and middle stage ankylosing spondylitis(deficiency of liver and kidney)after meridian moxibustion based on meridian injection theory.Methods A total of 124 patients with early and middle stage ankylosing spondylitis(liver and kidney deficiency syndrome)in our department from November 2020 to September 2022 were selected as the study objects,and were divided into a basic group of 62 cases,an observatior group of 62 cases,and a basic group of 62 cases receiving basic intervention such as methotrexate+loxoprofen sodium by mechanical sampling method.Observation group 62 cases were added to the meridian of ginger mud moxibustion based on the meridian flow theory,and compared the clinical improvement effect,spinal function,serum inflammatory factor levels,TCA key enzyme levels of the two groups.Results The scores of disease activity index(BASDAI),function index(BASFI),finger-ground distance and occipital wall distance in observation group were lower than those in basic group(P<0.05).There.was no significant difference in thoracic respiratory activity between the two groups(P>0.05).After intervention,the levels of inflammatory indicators C-reactive protein(CRP)in both groups were lower than before intervention(P<0.05),and the levels of inflammatory indicators in observation group were lower than those in basic group(P<0.05).After intervention,the level of a-ketoglutarate dehydrogenase(a-KGDHC)was higher than before intervention,and the levels of citric acid synthetase(CS)and isocitrie acid dehydrogenase(IDH)were lower than before intervention(P<0.05).The levels of a-KGDHC,CS and IDH TCA key enzymes in observation group were higher than those in basic group after intervention(P<0.05).Conclusions The moxibustion based on the theory of meridian injection can effectively improve the clinical symptoms and signs of patients with early and middle ankylosing spondylitis(liver and kidney deficiency syndro

关 键 词：子午流注理论 姜泥督灸 强直性脊柱炎 炎症因子 TCA关键酶 

分 类 号：R473.5[医药卫生—护理学]