应对老龄化所致慢病的智能生物材料  

Intelligent biomaterials for chronic diseases caused by aging

作　　者：袁月辉 黎谨 周亚鸣 朱雪菲 邵小东 方伦 刘一杨 金娟 王乐禹 李永生[6] 吴水林 蔡平强 胡本慧 顾宁 YUAN YueHui;LI Jin;ZHOU YaMing;ZHU XueFei;SHAO XiaoDong;FANG Lun;LIU YiYang;JIN Juan;WANG LeYu;LI YongSheng;WU ShuiLin;CAI PingQiang;HU BenHui;GU Ning(School of Biomedical Engineering and Informatics,Nanjing Medical University,Nanjing 211166,China;Affiliated Drum Tower Hospital,Medical School of Nanjing University,Nanjing 210008,China;The Fourth School of Clinical Medicine,Nanjing Medical University,Nanjing 210029,China;Medical School of Nanjing University,Nanjing 210093,China;School of Basic Medical Sciences,Guangzhou Medical University,Guangzhou 511436,China;School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China;School of Materials Science and Engineering,Peking University,Beijing 100871,China)

机构地区：[1]南京医科大学生物医学工程与信息学院,南京211166 [2]南京大学医学院附属鼓楼医院,南京210008 [3]南京医科大学第四临床医学院,南京210029 [4]南京大学医学院,南京210093 [5]广州医科大学基础医学院,广州511436 [6]华东理工大学材料科学与工程学院,上海200237 [7]北京大学材料科学与工程学院,北京100871

出　　处：《中国科学：技术科学》2024年第8期1519-1532,共14页Scientia Sinica(Technologica)

基　　金：国家自然科学基金创新研究群体项目(批准号:61821002);国家自然科学基金(批准号:51832001,81971701);江苏省前沿引领技术基础研究重大项目(编号:BK20222002);国家重点研发计划项目(编号:2019YFA0210104)资助。

摘　　要：人口老龄化进程的不断加速直接导致骨质疏松和心血管疾病等慢性病高发,对以组织修复材料为核心的临床治疗方法提出了巨大挑战.本综述通过回顾生物材料的发展历程,总结归纳了各阶段生物材料的优劣势,同时详细论述了老龄化病损组织修复所面临的组织功能和微环境稳态难以维持的难题,最后基于此探讨如何结合人工智能、材料生物学、影像组学等新兴技术,研发能感知生理病理微环境,适时响应和主动调控生物学效应,并全周期适配病损组织修复进程的新一代“自适应”智能生物材料.The increasing population aging directly correlates with the heightened prevalence of chronic ailments,including osteoporosis and cardiovascular diseases.This poses considerable challenges to clinical treatments focused on tissue repair materials.In this review,an overview of the developmental trajectory of biomaterials is provided,along with a discussion on the merits and demerits associated with their different developmental stages.Furthermore,intricacies involved in maintaining tissue function and microenvironment homeostasis during the aged and damaged tissue repair are analyzed.Lastly,building upon these insights,the utilization of emerging technologies,such as artificial intelligence,material biology,and imaging omics,for developing novel“adaptive”intelligent biomaterials capable of perceiving physiological and pathological microenvironments is explored.These materials would promptly respond and actively regulate biological effects during the entire tissue repair process at lesion sites.

关 键 词：老龄化疾病 材料生物学 智能生物材料 组织修复 

分 类 号：R318.08[医药卫生—生物医学工程]