内质网-线粒体互作与钙稳态  

Endoplasmic reticulum-mitochondrial interaction and calcium homeostasis

作　　者：屈川人 刘垒[1,2,3] QU ChuanRen;LIU Lei(Key Laboratory of Organ Regeneration and Intelligence,State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;College of Life Sciences,University of Chinese Academy of Sciences,Beijing 100101,China;Beijing Institute of Stem Cell and Regenerative Medicine,Beijing 100101,China)

机构地区：[1]中国科学院动物研究所,膜生物学国家重点实验室,器官再生与智造重点实验室,北京100101 [2]中国科学院大学生命科学学院,北京100101 [3]北京干细胞与再生医学研究院,北京100101

出　　处：《中国科学：生命科学》2024年第8期1327-1336,共10页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:92254301,32293201);国家重点研发计划(批准号:2020YFA0803702);中国科学院稳定支持基础研究领域青年团队计划(批准号:YSBR-075)资助。

摘　　要：内质网(endoplasmic reticulum, ER)是细胞中最大的细胞器之一,是细胞内的钙库,也是蛋白质合成与运输、蛋白质折叠、脂肪以及类固醇合成主要部位.线粒体是细胞内的能量工厂,参与细胞内的凋亡调控、氧化还原平衡、生物合成和信号转导,同时线粒体在钙稳态维持中也发挥着关键作用.内质网和线粒体外膜存在物理上的接触结构,这一结构被称为线粒体相关内质网膜(mitochondria-associated endoplasmic reticulum membranes,MAMs). MAMs在多种细胞通路中发挥着核心作用,参与包括线粒体动态、自噬、炎症反应、脂质代谢、钙稳态及内质网应激等多种生物学功能,并与多种疾病的发生发展密切相关.本文主要介绍MAMs的结构和分子组成,并重点围绕MAMs在钙稳态中的作用进行综述.The endoplasmic reticulum(ER)is one of the largest organelles in the cell,and is the main site of protein synthesis and transport,protein folding,lipid and steroid synthesis,as well as the intracellular calcium reservoir.Mitochondria are intracellular energy factories involved in apoptosis regulation,redox homeostasis,biosynthesis,and signal transduction,and they also play a key role in the maintenance of calcium homeostasis.The endoplasmic reticulum and the outer mitochondrial membrane are in physical contact with each other in a structure known as mitochondria-associated endoplasmic reticulum membranes(MAMs).MAMs play a central role in a variety of cellular pathways,including mitochondrial dynamics,autophagy,inflammation,lipid metabolism,calcium homeostasis etc,and are closely related to the development of many diseases.This article introduces the structure and molecular composition of MAMs and focuses on the role of MAMs in calcium homeostasis.

关 键 词：线粒体 内质网 线粒体相关内质网膜 钙稳态 

分 类 号：Q25[生物学—细胞生物学]