细胞辅助脂肪移植技术修复难愈性创面的作用机制研究进展  

Mechanism of effects of cell‑assisted lipotransfer technique in refractory wound repair:a review

作　　者：田苗苗 李云鹏 张敬雨 刘富伟 张浚睿 孔亮 陆斌 李治冶 Tian Miaomiao;Li Yunpeng;Zhang Jingyu;Liu Fuwei;Zhang Junrui;Kong Liang;Lu Bin;Li Zhiye(School of Basic Medical Sciences,Air Force Medical University,Xi′an 710032,China;Department of Oral and Maxillofacial Surgery,Third Affiliated Hospital,Air Force Medical University,Shaanxi Clinical Research Center for Oral Diseases,State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration,National Clinical Research Center for Oral Diseases,Xi′an 710032,China)

机构地区：[1]空军军医大学基础医学院,西安710032 [2]空军军医大学第三附属医院颌面外科,陕西省口腔疾病临床医学研究中心,口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,西安710032

出　　处：《中华创伤杂志》2024年第8期753-759,共7页Chinese Journal of Trauma

基　　金：国家自然科学基金青年科学基金(81801969);国家自然科学基金面上项目(81970988);空军军医大学第三附属医院2022年度临床新技术新业务项目(LX2022‑307)。

摘　　要：创面愈合是一个复杂的生物整合过程,愈合过程中一旦出现过度炎症反应、细胞增殖迁移及细胞分泌障碍等不良情况时,就会形成难愈性创面。其病因复杂、病情迁延,发病率和复发率均较高,严重损害患者的身心健康。临床上难愈性创面主要通过手术清创、皮肤移植进行治疗,但存在手术创伤大、恢复时间长、病情易反复等问题。近年来,得益于干细胞的多向分化潜能、免疫调节及旁分泌等功能,细胞辅助脂肪移植(CAL)技术将自身脂肪干细胞(ADSCs)与颗粒脂肪混合后进行体内注射以修复难愈性创面,并展现出广阔的应用前景。明确CAL技术修复难愈性创面的作用机制对其临床应用具有重要意义。笔者就CAL技术修复难愈性创面的作用机制研究进展进行综述,为难愈性创面修复的相关研究和治疗提供参考。Wound healing is a complex process of biological integration in which the adverse conditions such as excessive inflammatory reactions,cell proliferation and migration disorders,and cellular secretion impairment can lead to refractory wounds.Characterized by complex etiology,protracted condition,and high morbidity and recurrence rate,refractory wounds severely impair patients′physical and mental health.In clinical practice,refractory wounds are primarily treated with surgical debridement and skin transplantation,but there still exist problems such as large surgical wounds,prolonged recovery time,and high recurrence rate.In recent years,owing to the multipotent differentiation,immunomodulatory,and paracrine functions of stem cells,cell‑assisted lipotransfer(CAL)technique,which involves intra‑body injection of a mixture of autologous adipose‑derived stem cells(ADSCs)and granular fat for refractory wound repair,has demonstrated promising application prospects.It is of great significance in its clinical application to clarify the mechanism of effects of CAL technique in refractory wound repair.The authors reviewed the research progress in the mechanism of effects of CAL technique in repairing refractory wounds to provide references for the research and treatment of refractory wounds.

关 键 词：伤口愈合 间质干细胞移植 创面修复 

分 类 号：R622[医药卫生—整形外科]