维生素B_(2)、维生素C和维生素B_(6)在铜掺杂聚L-谷氨酸/功能化多壁碳纳米管传感界面上的同时电化学行为  

Simultaneous electrochemical behavior of vitamin B_(2),vitamin C and vitamin B_(6)at the sensing interface of copper-doped poly-L-glutamate/functionalized multi-walled carbon nanotubes

作　　者：郑瑞康 王榕 应美辰 于力山 刘楠 姜先浩 冯德香 尉艳 ZHENG Ruikang;WANG Rong;YING Meichen;YU Lishan;LIU Nan;JIANG Xianhao;FENG Dexiang;WEI Yan(Schol of Pharmacy,Wannan Medical College,Wuhu 241002,China)

机构地区：[1]皖南医学院药学院,芜湖241002

出　　处：《分析试验室》2024年第8期1109-1117,共9页Chinese Journal of Analysis Laboratory

基　　金：国家自然科学基金(21645006);安徽高校自然科学研究重大项目(2023AH040250);安徽高然科学研究重点项目(KJ2021A0842);安徽省大学生创新创业训练计划项目(S202210368057)资助。

摘　　要：采用电聚合结合共价键合,制备了铜掺杂聚L-谷氨酸/功能化多壁碳纳米管传感界面,构建可同时测定维生素B_(2)(VB_(2))、维生素C(VC)和维生素B_(6)(VB_(6))的传感器。该传感界面对3种维生素皆具有优良的电催化氧化性能:于0.1 mol/L的磷酸盐缓冲体系(pH 1.0)中,利用循环伏安法(CV)测得VB_(2),VC和VB_(6)的氧化峰电位分别为-153,264和1140 mV;采取示差脉冲伏安法(DPV)测定,VB_(2),VC和VB_(6)的线性范围分别为1~2800μmol/L、10~12000μmol/L和10~13000μmol/L,检出限分别为0.3,3.0和3.2μmol/L。该传感器应用于实际样本检测的回收率在97.8%~101.4%之间。A copper-doped poly-L-glutamate/functionalized multi-walled carbon nanotubes(MWCNT)sensing interface was prepared for the simultaneous determination of vitamin B_(6)(VB,),vitamin C(VC),and vitamin B_(2)(VB_(2))by combining electropolymerization and covalent bonding.This sensor exhibited excellent electrocatalytic oxidation performance for the three vitamins.The cyclic voltammetry(CV)peak potentials of VB_(2),VC,and VB_(6)were-153,264 and 1140 mV,respectively in a 0.1 mol/L phosphate buffer solution(pH 1.0).The differential pulse voltammetry(DPV)peak currents obtained increased linearly for VB_(2),VC and VB_(6)in the concentration ranges of 1 to 2800 mol/L,10 to 12000μmol/L and 10 to 13000μmol/L,with the detection limits for VB_(2),VC,and VB_(6)being 0.3,3.0,and 3.2μmol/L,respectively.And the recoveries of VB_(2),VC,and VB,in the multiple vitamin tablets were 97.8%-101.4%.

关 键 词：维生素B_(2) 维生素C 维生素B_(6) 电化学传感 同时测定 

分 类 号：R917[医药卫生—药物分析学] O657.1[医药卫生—药学]