Co-NH_(2)-BDC-L-羟基脯氨酸用作高效液相色谱手性固定相  

Co-NH_(2)-BDC-L-hydroxyproline used as a chiral stationary phase in high performance liqiud chromatography

作　　者：蒋雪菲 高顺秋 郑康妮 普娜 袁黎明[1] JIANG Xuefei;GAO Shunqiu;ZHENG Kangni;PU Na;YUAN Liming(School of Chemistry and Chemical Engineering,Yunnan Normal University,Kunming 650500,China)

机构地区：[1]云南师范大学化学化工学院,昆明650500

出　　处：《分析试验室》2024年第8期1118-1123,共6页Chinese Journal of Analysis Laboratory

基　　金：国家自然科学基金(22174125)资助。

摘　　要：采用L-羟基脯氨酸对金属有机框架材料Co-NH_(2)-BDC进行修饰,制备了手性Co-NH_(2)-BDC-L-羟基脯氨酸材料。采用“网包法”,将该材料涂敷于硅胶表面,得到了Co-NH_(2)-BDC-L-羟基脯氨酸手性固定相。考察了固定相的手性拆分能力,使用正己烷/异丙醇、甲醇/水作为流动相,使用该固定相拆分了24种手性化合物和5种苯系位置异构体。结果表明,所制备的手性色谱柱具有良好的手性拆分能力,在手性物质和苯系位置异构体分离中具有一定的应用价值。The chiral Co-NH_(2)-BDC-L-hydroxyproline was prepared by modifying metal-organic frameworks of Co-NH_(2)-BDC with L-hydroxyproline.The Co-NH_(2)-BDC-L-hydroxyproline chiral stationary phase was obtained by coating the material on the surface of silica gel through"mesh coating method".The 24 chiral compounds and 5 benzene isomers were resolved by using n-hexane/isopropyl alcohol and methanol/water as mobile phases.The results show that the prepared chiral column possesses favorable chiral separation ability and owns certain application value in the separation of chiral substances and benzene position isomers.

关 键 词：金属有机框架 L-羟基脯氨酸 高效液相色谱 手性拆分 

分 类 号：O652.6[理学—分析化学] O657.7[理学—化学]