围产期解脲脲原体感染的诊治进展  

Advances in the diagnosis and treatment of ureaplasma urealyticum infection during perinatal period

作　　者：李洋丽 袁天明[1] LI Yangli;YUAN Tianming(Department of Neonatology,Children’s Hospital,Zhejiang University School of Medicine,Zhejiang,Hangzhou 310052,China)

机构地区：[1]浙江大学医学院附属儿童医院新生儿科,浙江杭州310052

出　　处：《中国医药科学》2024年第15期52-56,共5页China Medicine And Pharmacy

摘　　要：解脲脲原体是女性生殖道的常见共生体,可通过垂直传播导致胎儿感染,是绒毛膜羊膜炎和早产的主要致病菌。产前、围产期或产后传播可能导致新生儿脲原体感染。这可能表现为急性侵袭性感染,例如肺炎和败血症,也可能表现为慢性炎症如支气管肺发育不良等。解脲脲原体种类的检测有一定困难,且临床上不作为常规检测项目。目前对于早产儿解脲脲原体感染的治疗尚无统一标准,足月新生儿解脲脲原体定植、妊娠期解脲脲原体定植是否需要治疗尚无定论。本文通过复习既往文献,讨论解脲脲原体感染的致病机制、临床结局和目前的诊断及治疗进展。Ureaplasma urealyticum is a common commensal in the female genital tract that can lead to fetal infection through vertical transmission.It is the main causative agent of chorioamnionitis and preterm labor.Antenatal,perinatal or postnatal transmission may result in neonatal ureaplasma infection.This may present as acute invasive infections such as pneumonia and sepsis,or as chronic inflammation such as bronchopulmonary dysplasia.Detection of ureaplasma urealyticum species is difficult and is not routinely done in clinical practice.Currently,there are no standardized criteria for the treatment of ureaplasma urealyticum infection in preterm infants.Meanwhile,whether treatment is necessary for ureaplasma urealyticum colonization in full-term neonates and during pregnancy is still unclear.This paper discusses the pathogenesis,clinical outcomes,and current advances in the diagnosis and treatment of ureaplasma urealytic um infection by reviewing the previous literature.

关 键 词：解脲脲原体 感染 新生儿 围产期 

分 类 号：R714.7[医药卫生—妇产科学]