中药脐疗治疗溃疡性结肠炎缓解期疗效观察  

Effect observation on umbilical therapy with traditional Chinese medicine combined with nursing intervention in the treatment of ulcerative colitis in remission stage

作　　者：李静[1] 高海波[1] 刘兰香 LI Jing;GAO Haibo;LIU Lanxiang(Department of Gastroenterology,Gaomi People’s Hospital Affiliated to Shandong Second Medical University,Shandong,Gaomi 261500,China)

机构地区：[1]潍坊医学院附属高密市人民医院消化内科,山东高密261500

出　　处：《中国医药科学》2024年第15期106-109,共4页China Medicine And Pharmacy

基　　金：山东省潍坊市中医药科研计划项目(2021-4-144)。

摘　　要：目的观察中药脐疗干预治疗溃疡性结肠炎缓解期临床效果。方法选取2021年1月至2023年3月在潍坊医学院附属高密市人民医院消化内科就诊溃疡性结肠炎缓解期患者,按照随机数表法分为治疗组、对照组,每组各35例。对照组口服美沙拉嗪肠溶片1.0 g,tid;治疗组同时给予中药脐疗“十味抗炎方”凝胶剂。采用改良Mayo评分评价溃疡性结肠炎严重程度;溃疡性结肠炎疾病活动指数评价疾病活动度;炎症性肠病生存量表评价生存质量;检查炎症因子白细胞介素-6、白细胞介素-8和肿瘤坏死因子-α;选择抑郁自评量表和焦虑自评量表评价患者心理情况。结果治疗组第5、6个月Mayo评分和疾病活动指数得分低于对照组,差异有统计学意义(P<0.05);治疗组第3、4、5、6个月炎症性肠病生存量表得分高于对照组,差异有统计学意义(P<0.05);治疗组第3、6个月炎症因子低于对照组,差异有统计学意义(P<0.05);治疗组第3、6个月抑郁和焦虑自评量表评分低于对照组,差异有统计学意义(P<0.05)。结论中药脐疗提升患者生活质量,改善预后,临床疗效优于对照组。Objective To observe the clinical effect of umbilical therapy with traditional Chinese medicine combined with nursing intervention on ulcerative colitis(UC)in remission stage.Methods A total of 70 patients with UC in remission admitted to the Department of Gastroenterology,Gaomi People’s Hospital Affiliated to Shandong Second Medical University from January 2021 to March 2023 were selected and divided into the treatment group and the control group by random number table method,with 35 patients in each group.The control group took orally mesalazine enteric-coated tablets 1.0 g tid,while the treatment group was given"Shiwei Kangyan Recipe"gel and continuous nursing intervention.The severity of UC was evaluated by modified Mayo score(MMC).Ulcerative colitis disease activity index(UCDAI)was used to evaluate the disease activity.The inflammatory bowel disease questionnaire(IBDQ)was used to evaluate the quality of life.Inflammatory factors such as interleukin(IL)-6 and IL-8 and tumor necrosis factor-α(TNF-α)were examined.Self-rating depression scale(SDS)and self-rating anxiety scale(SAS)were adopted to evaluate the psychological situation of UC patients.Results The scores of MMC and UCDAI in the treatment group were lower than those in the control group at the 5th and 6th month,with statistically significant differences(P<0.05).The score of IBDQ in the treatment group was higher than that in the control group at the 3rd,4th,5th and 6th month,with statistically significant difference(P<0.05).The levels of inflammatory factors in the treatment group were lower than those in the control group at the 3rd and 6th month,with statistically significant differences(P<0.05).The scores of SDS and SAS in the treatment group were lower than those in the control group at the 3rd and 6th month,with statistically significant differences(P<0.05).Conclusion The combination of umbilical therapy with traditional Chinese medicine and continuous nursing in the treatment group can improve the quality of life of patients and improve the p

关 键 词：溃疡性结肠炎 脐疗 中西医结合 临床研究 

分 类 号：R259[医药卫生—中西医结合]