复方制剂雌二醇片/雌二醇地屈孕酮片治疗妇女围绝经期综合征的临床效果研究  

A Clinical Study on the Therapeutic Effect of Compound Preparation Es⁃tradiol Tablets/Estradiol and Dydrogesterone Tablets on Perimenopausal Syndrome in Women

作　　者：温泉 肖瑛 WEN Quan;XIAO Ying(Gynecology Department,Ganzhou Maternal and Child Health Hospital,Ganzhou 341000,Jiangxi,China)

机构地区：[1]赣州市妇幼保健院妇科,江西赣州341000

出　　处：《中外医疗》2024年第19期89-92,共4页China & Foreign Medical Treatment

摘　　要：目的 研究对围绝经期综合征妇女应用复方制剂雌二醇片/雌二醇地屈孕酮片治疗的临床效果。方法 单纯随机选取2022年1—12月赣州市妇幼保健院收治的80例围绝经期综合征患者为研究对象。使用红蓝信封法分为对照组和研究组,每组40例。对照组患者行戊酸雌二醇片治疗,研究组患者行复方制剂雌二醇片/雌二醇地屈孕酮片治疗。比较两组患者临床效果。结果 治疗前,两组患者性激素水平变化对比,差异无统计学意义(P>0.05);治疗后,研究组患者黄体生成素(13.23±5.23)IU/L、卵泡生成素(23.63±7.44)IU/L均低于对照组,雌二醇水平(71.23±10.23)pmoL/L高于对照组,差异有统计学意义(P均<0.05)。研究组患者临床有效率(95.00%)高于对照组(80.00%),差异有统计学意义(χ^(2)=4.114,P=0.042)。研究组患者不良反应总发生率(2.50%)低于对照组(12.50%),差异有统计学意义(χ^(2)=3.913,P=0.047)。结论 对围绝经期综合征患者应用复方制剂雌二醇片/雌二醇地屈孕酮片治疗,可改善患者激素水平,提升治疗有效率,安全性高。Objective To study the clinical effect of compound preparation estradiol tablets/estradiol and dydrogester-one tablets in the treatment of perimenopausal syndrome women.Methods A total of 80 menopausal syndromel patients admitted to Ganzhou Maternal and Child Health Hospital from January to December 2022 were simple and randomly se-lected as the study subjects.Using the red and blue envelope method,they were divided into the reference group and the study group,with 40 cases in each group.The reference group was treated with estradiol valerate tablets.The study group was treated with compound preparation estradiol tablets/estradiol and dydrogesterone tablets.The clinical effects of the two groups were compared.Results Before treatment,there was no significant difference in the changes of sex hor-mones between the two groups(P>0.05).After treatment,the levels of luteinizing hormone was(13.23±5.23)IU/L and follicle stimulating hormone was(23.63±7.44)IU/L in the study group,which were lower than those in the reference group,and the level of estradiol was(71.23±10.23)pmoL/L in the study group,which was higher than that in the refer-ence group,the differences were statistically significant(all P<0.05).The clinical effective rate of the study group(95.00%)was higher than that of the reference group(80.00%),and the difference was statistically significant(χ^(2)=4.114,P=0.042).The total incidence of adverse reactions in the study group(2.50%)was lower than that in the refer-ence group(12.50%),and the difference was statistically significant(χ^(2)=3.913,P=0.047).Conclusion The application of compound preparation tablets/estradiol and dydrogesterone tablets in the treatment of menopausal syndrome patients can improve the hormone level of patients,and improve the efficiency of treatment,with high safety.

关 键 词：雌二醇片/雌二醇地屈孕酮片 围绝经期综合征 性激素 疗效 

分 类 号：R711[医药卫生—妇产科学]