甘露醇联合七叶皂苷钠治疗创伤性脑水肿的临床效果及安全性分析  

Analysis of the Clinical Efficacy and Safety of Mannitol Combined with Sodium Aescinate in the Treatment of Traumatic Brain Edema

作　　者：杨德华 石铃铃 段绍斌 YANG Dehua;SHI Lingling;DUAN Shaobin(Songtao Miao Autonomous County Ethnic Traditional Chinese Medicine Hospital,Tongren 554100,Guizhou,China)

机构地区：[1]松桃苗族自治县民族中医院,贵州铜仁554100

出　　处：《中外医疗》2024年第20期1-4,共4页China & Foreign Medical Treatment

摘　　要：目的探讨甘露醇联合七叶皂苷钠治疗创伤性脑水肿的临床效果及安全性。方法方便选取松桃苗族自治县民族中医院于2020年12月—2023年12月期间收治的92例创伤性脑水肿患者为研究对象,依据不同治疗方法分为对照组和观察组,各46例。对照组在常规治疗的基础上采用甘露醇治疗,而观察组则在对照组基础上加入七叶皂苷钠的治疗,比较两组患者的脑水肿干预效果、神经功能缺损程度、昏迷指数、神经功能以及安全性。结果治疗后,观察组的脑水肿体积小于对照组,治疗总有效率高于对照组,差异有统计学意义(t=23.122,χ^(2)=3.903,P均<0.05)。观察组的改良爱丁堡-斯堪的纳维亚评分为(14.79±2.02)分,低于对照组的(17.51±2.38)分,差异有统计学意义(t=5.910,P<0.05)。观察组的拉斯哥昏迷指数得分高于对照组,美国国立卫生研究院卒中量表评分低于对照组,差异有统计学意义(t=7.363、7.631,P均<0.05)。两组患者治疗期间,未观察到任何显著的不良反应。结论甘露醇联合七叶皂苷钠治疗创伤性脑水肿显示出良好的疗效和安全性,尤其是在减少脑水肿体积和改善神经功能方面显著优于单纯使用甘露醇的传统治疗方法。Objective To investigate the clinical effect and safety of mannitol combined with sodium aescinate in the treatment of traumatic brain edema.Methods A total of 92 patients with traumatic cerebral edema admitted to the Songtao Miao Autonomous County Ethnic Traditional Chinese Medicine Hospital from December 2020 to December 2023 were conveniently selected as the study subjects.According to different treatment methods,they were divided into control group and observation group,with 46 cases in each group.The control group was treated with mannitol on the basis of conventional treatment,while the observation group was treated with sodium aescinate on the basis of control group.The intervention effect of cerebral edema,degree of neurological impairment,coma index,neurological function and safety of the two groups were compared.Results After treatment,the cerebral edema volume in the observation group was smaller than that in the control group,and the effective rate was greater than that in the control group,the differences were statistically significant(t=23.122,χ^(2)=3.903,both P<0.05).The Modified Edinburgh-Scandinavianstroke Scale score of the observation group was(14.79±2.02)points,lower than that of the control group(17.51±2.38)points,and the difference was statistically significant(t=5.910,P<0.05).The score of Glasgow Coma Scale in the observation group was higher than that in the control group,and the score of National Institutes of Health Stroke Scale was lower than that in the control group,the differences were statistically significant(t=7.363,7.631,both P<0.05).During the treatment of the two groups of patients,no significant adverse reactions were observed.Conclusion Mannitol combined with sodium aesculin in the treatment of traumatic brain edema showed good efficacy and safety,especially in reducing the volume of brain edema and improving nerve function significantly superior to the traditional treatment of mannitol alone.

关 键 词：甘露醇 七叶皂苷钠 创伤性脑水肿 临床效果 安全性 

分 类 号：R651.15[医药卫生—外科学]