对老年急性脑梗死患者采取丁苯酞与抗血小板聚集药物联合治疗的临床效果分析  

Clinical Effect Analysis of Combined Treatment of Butylphthalein and Antiplatelet Aggregation Drugs in Elderly Patients with Acute Cerebral Infarction

作　　者：孙锦涛 朱泓硕 朱丽 SUN Jintao;ZHU Hongshuo;ZHU Li(Department of Neurology,Nanjing Brain Hospital,Nanjing 210029,Jiangsu,China;Department of Psychiatry,Yancheng Fourth People's Hospital,Yancheng 224000,Jiangsu,China)

机构地区：[1]南京脑科医院神经内科,江苏南京210029 [2]盐城市第四人民医院精神科,江苏盐城224000

出　　处：《中外医疗》2024年第20期25-28,共4页China & Foreign Medical Treatment

摘　　要：目的探讨对老年急性脑梗死患者给予丁苯酞联合抗血小板聚集药物联合治疗的临床效果。方法随机选取2021年1—12月南京脑科医院收治的80例老年急性脑梗死患者为研究对象,用随机数表法将患者分为对照组和研究组,每组40例。对照组患者采用抗血小板聚集药物治疗,研究组患者在对照组治疗的基础上加用丁苯酞,对两组患者的治疗效果、神经功能缺损情况、血流动力学指标、炎性因子水平等进行分析比较。结果研究组患者治疗总有效率(95.00%)高于对照组(80.00%),差异有统计学意义(χ^(2)=4.114,P<0.05);研究组患者收缩期最大血流速度、大脑后动脉平均血流速度高于对照组,国立卫生研究院卒中量表评分、阻力指数指标低于对照组,差异有统计学意义(P均<0.05);研究组患者的炎性因子水平低于对照组,差异有统计学意义(P<0.05)。结论对老年急性脑梗死患者给予丁苯酞联合抗血小板聚集药物治疗,能改善患者神经功能以及血流动力学指标,降低其炎性因子水平,治疗效果明显。Objective To investigate the clinical effect of butylphthalide combined with antiplatelet aggregation drugs in elderly patients with acute cerebral infarction.Methods A total of 80 elderly patients with acute cerebral infarction admitted to Nanjing Brain Hospital from January to December 2021 were randomly selected as the research objects.The patients were divided into control group and study group by random number table method,with 40 cases in each group.The patients in the control group were treated with antiplatelet aggregation drugs,and the patients in the study group were treated with butylphthalide on the basis of the control group.The therapeutic effect,neurological deficits,hemodynamic indexes and inflammatory factor levels of the two groups were analyzed and compared.Results The total therapeutic effect of the study group(95.00%)was higher than that of the control group(80.00%),and the difference was statistically significant(χ^(2)=4.114,P<0.05).The systolic velocity and mean velocity of the study group were higher than those of the control group,and the National Institute of Health Stroke Scale score and resist index were lower than those of the control group,the differences were statistically significant(all P<0.05).The level of inflammatory factors in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion The treatment of elderly patients with acute cerebral infarction with butylphthalide combined with antiplatelet aggregation drugs can improve the neurological function and hemodynamic indexes of patients,reduce the level of inflammatory factors,and the treatment effect is obvious.

关 键 词：老年 急性脑梗死 丁苯酞 抗血小板聚集药物 血流动力学 炎性因子 

分 类 号：R4[医药卫生—临床医学]