不同促排卵方案应用于卵巢储备功能减退患者中的效果分析  

Analysis of the Effects of Different Ovulation Induction Regimens on Patients with Diminished Ovarian Reserve

作　　者：欧玲 张辉娟 李婷 OU Ling;ZHANG Huijuan;LI Ting(Reproductive Medicine Center,Qiandongnan Miao and Dong Autonomous Prefecture Traditional Chinese Medicine Hospital,Qiandongnan Miao and Dong Autonomous Prefecture 556000,Guizhou,China)

机构地区：[1]黔东南苗族侗族自治州中医医院生殖医学中心,贵州黔东南556000

出　　处：《中外医疗》2024年第20期33-36,41,共5页China & Foreign Medical Treatment

摘　　要：目的探讨不同促排卵方案应用于卵巢储备功能减退患者中的效果。方法简单随机选取2022年6月—2023年12月黔东南苗族侗族自治州中医医院收治的40例卵巢储备功能减退行体外受精-胚胎移植(In Vitro Fertilization-embryo Transfer,IVF-ET)的患者为研究对象,按不同促排卵方案分为微刺激方案组和卵泡期高孕激素促排卵(Progestin Primed Ovarian Stimulation,PPOS)方案组,每组20例。对比两组促排卵及胚胎情况、血清雌激素[孕酮(Progesterone,P)、雌二醇(Estradiol,E_(2))、黄体生成素(Luteinising Hormone,LH)]水平、临床结局。结果微刺激方案组早发LH峰率(30.00%)高于PPOS方案组(0),差异有统计学意义(χ^(2)=4.902,P=0.027)。人绒毛膜促性腺激素(Human Chorionic Gonadotrophin,HCG)注射日,微刺激方案组血清LH高于PPOS方案组,差异有统计学意义(P<0.05)。两组血清E_(2)、P水平对比,差异无统计学意义(P均>0.05)。两组胚胎种植率、生化妊娠率、临床妊娠率对比,差异无统计学意义(P均>0.05)。结论微刺激方案、PPOS方案应用于卵巢储备功能衰退患者产生的临床结局相近,而PPOS方案可以降低早发LH峰的发生率。Objective To investigate the effect of different ovulation induction regimens in patients with Diminished Ovarian Reserve.Methods From June 2022 to December 2023,40 patients with diminished ovarian reserve undergoing in vitro fertilization-embryo transfer(IVF-ET)in Qiandongnan Miao and Dong Autonomous Prefecture Traditional Chinese Medicine Hospital were simple randomly selected as the research objects.According to different ovulation induction schemes,they were divided into microstimulation group and progestin primed ovarian stimulation(PPOS)scheme group,with 20 cases in each group.Ovulation induction and embryo status,serum estrogen[progesterone(P),estradiol(E_(2)),luteinising hormone(LH)]levels and clinical outcomes of the two groups were compared.Results The early LH peak rate in the microstimulation group(30.00%)was higher than that in the PPOS group(0),and the difference was statistically significant(χ^(2)=4.902,P=0.027).On the day of human chorionic gonadotrophin(HCG)injection,serum LH in the microstimulation group was higher than that in the PPOS group,and the difference was statistically significant(P<0.05),while there was no statistically significant difference in serum E_(2) and P levels between the two groups(both P>0.05).There was no significant difference in embryo implantation rate,biochemical pregnancy rate and clinical pregnancy rate between the two groups(all P>0.05).Conclusion There is no significant difference in clinical outcomes between microstimulation and PPOS in patients with ovarian reserve decline,while PPOS can reduce the incidence of early LH peak.

关 键 词：卵巢储备功能减退 体外受精-胚胎移植 微刺激方案 卵泡期高孕激素促排卵 

分 类 号：R711[医药卫生—妇产科学]