含利福喷丁与含利福平抗结核方案治疗初治肺结核效果及对肝功能影响的比较分析  

Comparative Analysis of the Effects of Rifapentine-containing and Rifampicin-Containing Anti-tuberculosis Regimens on Newly Diagnosed Pulmonary Tuberculosis and Their Effects on Liver Function

作　　者：赵玉杭[1] 黄玲[1] 谢文芳 李佳[1] ZHAO Yuhang;HUANG Ling;XIE Wenfang;LI Jia(Department of Tuberculosis Prevention and Control,Fuzhou Center for Disease Control and Prevention,Fuzhou 350200,Fujian,China;Fuzhou Tuberculosis Prevention and Control Hospital,Fuzhou 350007,Fujian,China)

机构地区：[1]福州市疾病预防控制中心结核病防治科,福建福州350200 [2]福州结核病防治院,福建福州350007

出　　处：《中外医疗》2024年第20期96-99,共4页China & Foreign Medical Treatment

摘　　要：目的分析比较含利福喷丁与含利福平抗结核方案对初治肺结核患者的疗效。方法回顾性选取2021年9月—2023年9月福州结核病防治院收治的92例初治肺结核患者的临床资料,按治疗方法不同分为对照组和观察组,每组各46例。对照组行含利福平抗结核方案治疗,观察组行含利福喷丁抗结核方案治疗。比较两组患者的痰菌阴转率、临床疗效、炎症因子水平、肝功能、不良反应。结果观察组痰菌阴转率为95.65%、治疗总有效率为97.83%,高于对照组的82.61%、82.61%,不良反应发生率为6.52%,低于对照组的21.74%,差异有统计学意义(χ^(2)=4.039、4.434、4.389,P=0.044、0.035、0.036)。治疗后,观察组炎症因子水平、肝功能指标均低于对照组,差异有统计学意义(P均<0.05)。结论含利福喷丁抗结核方案更能够加快初治肺结核患者的痰菌阴转,减轻炎症反应与肝功能损伤,且不良反应更少,值得临床借鉴研究。Objective To analyze and compare the efficacy of rifapentine-containing and rifampin-containing antituberculosis regimens in patients with newly diagnosed pulmonary tuberculosis.Methods The clinical data of 92 patients with newly diagnosed pulmonary tuberculosis admitted to Fuzhou Tuberculosis Prevention and Control Hospital from September 2021 to September 2023 were retrospectively selected and divided into control group and observation group according to different treatment methods,with 46 cases in each group.The control group was treated with rifampicin-containing anti-tuberculosis regimen,and the observation group was treated with rifapentine-containing anti-tuberculosis regimen.The sputum negative conversion rate,clinical efficacy,inflammatory factor level,liver function and adverse reactions were compared between patients in two groups.Results The sputum negative conversion rate of the observation group was 95.65%,the total effective rate of treatment was 97.83%,which were higher than 82.61%and 82.61%of the control group,and the incidence of adverse reactions was 6.52%,which was lower than 21.74%of the control group,the differences were statistically significant(χ^(2)=4.039,4.434,4.389,P=0.044,0.035,0.036).After treatment,the levels of inflammatory factors and liver function indexes in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).Conclusion The rifapentine-containing anti-tuberculosis regimen can accelerate the sputum negative conversion of newly diagnosed pulmonary tuberculosis patients,reduce inflammation and liver function damage,and have fewer adverse reactions,which is worthy of clinical reference.

关 键 词：初治肺结核 利福喷丁 利福平 肝功能 炎症因子 

分 类 号：R521[医药卫生—内科学]