桔葶六安煎联合常规疗法治疗慢性阻塞性肺疾病急性加重期患者的临床效果观察  

Clinical Effect Observation of Jietingliuan Decoction Combined with Conventional Therapy in Treatment of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：刘宗伟 文高艳 Liu Zongwei;Wen Gaoyan(Respiratory Department,Lianyungang Hospital of Traditional Chinese Medicine Affiliated to Kangda College of Nanjing Medical University,Nanjing 222000,Jiangsu Province,China)

机构地区：[1]南京医科大学康达学院附属连云港中医院呼吸科,江苏南京222000

出　　处：《中国社区医师》2024年第19期73-75,共3页Chinese Community Doctors

基　　金：南京医科大学康达学院科研发展(编号:KD2022KYJJZD118)。

摘　　要：目的:分析桔葶六安煎联合常规疗法治疗慢性阻塞性肺疾病急性加重期患者的临床效果。方法:选取2022年1月—2023年3月南京医科大学康达学院附属连云港中医院收治的慢性阻塞性肺疾病急性加重期患者60例作为研究对象,以随机数字表法分为对照组、试验组,各组30例。对照组患者采取抗感染、缓解气道痉挛、祛痰等对症治疗,试验组在对照组基础上采用桔葶六安煎治疗。比较两组临床治疗效果、治疗前后血清炎性指标、不良反应发生率。结果:试验组患者治疗总有效率比对照组高(P<0.05)。治疗前,两组患者降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-6(IL-6)、人可溶性髓系细胞触发受体-1(sTREM-1)水平无差异(P>0.05);治疗后,两组患者PCT、CRP、IL-6及sTREM-1水平均下降,且试验组PCT、CRP、IL-6及sTREM-1水平低于对照组(P<0.05)。两组不良反应发生率无差异(P>0.05)。结论:桔葶六安煎联合常规疗法治疗慢性阻塞性肺疾病急性加重期患者的临床效果显著,能够改善患者病情,减轻炎性反应,且不会增加不良反应。Objective:To analyze the clinical effect of Jietingliuan Decoction combined with conventional therapy in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease.Methods:A total of 60 patients with acute exacerbation of chronic obstructive pulmonary disease admitted to Lianyungang Hospital of Traditional Chinese Medicine Affiliated to Kangda College of Nanjing Medical University from January 2022 to March 2023 were selected as the study subjects.They were divided into control group and experimental group by random number table method,with 30 patients in each group.The control group was treated with anti-infection,airway spasm relieving,phlegm expelling and other symptomatic treatments.The experimental group was treated with Jietingliuan Decoction on the basis of the control group.The clinical treatment effect,serum inflammatory indexes before and after treatment,and the incidence of adverse reactions were compared between two groups.Results:The total effective rate of treatment in the experimental group was higher than that in the control group(P<0.05).Before treatment,there was no difference in the levels of procalcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6)and human soluble triggering receptor expressed on myeloid cell-1(sTREM-1)between the two groups(P>0.05).After treatment,the levels of PCT,CRP,IL-6 and sTREM-1 in the two groups decreased,and the levels of PCT,CRP,IL-6 and sTREM-1 in the experimental group were lower than those in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Jietingliuan Decoction combined with conventional therapy has significant clinical effects in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease,and can improve the condition of patients,relieve inflammatory reactions,and will not increase adverse reactions.

关 键 词：慢性阻塞性肺疾病 急性加重期 桔葶六安煎 

分 类 号：R256.11[医药卫生—中医内科学]