发热伴血小板减少综合征病毒感染免疫逃逸机制研究进展  

Research advance on immune escape mechanism in fever with thrombocytopenic syndrome virus infection

作　　者：李倩[1] 李军政 王伟[1] 石清明[1] LI Qian;LI Junzheng;WANG Wei;SHI Qingming(Center for Disease Control and Prevention of Western Theater of the People's Liberation Army of China,Lanzhou,Gansu 730020,China)

机构地区：[1]中国人民解放军西部战区疾病预防控制中心,甘肃兰州730020

出　　处：《热带医学杂志》2024年第7期1062-1066,共5页Journal of Tropical Medicine

基　　金：军队生物安全项目(AWS21J007)。

摘　　要：发热伴血小板减少综合征(SFTS)是由发热伴血小板减少综合征病毒(SFTSV)引起的一种新发传染病,我国至少25个省份已监测到感染病例。SFTS患者病死率高、发病机制复杂,免疫逃逸在病毒大量复制增殖中起重要作用,与患者疾病进展和预后密切相关。本文围绕病毒感染后固有免疫和适应性免疫逃逸两方面机制作一综述,为加深理解免疫逃逸致病机制、开发针对性治疗手段提供依据。Severe fever with thrombocytopenia syndrome(SFTS)is an emerging infectious disease caused by fever with thrombocytopenia syndrome virus(SFTSV),and cases of infection have been monitored in at least 25 provinces in China.Patients with SFTS have a high mortality rate and complex pathogenesis,and immune escape plays an important role in the mass replication and proliferation of viruses,which is closely related to the disease progression and prognosis of patients.This article focuses on the two mechanisms of innate immunity and adaptive immune escape after viral infection,in order to provide a basis for deepening the understanding of the pathogenic mechanism of immune escape and developing targeted treatment methods.

关 键 词：发热伴血小板减少综合征 免疫逃逸 干扰素抑制 B细胞 T细胞 

分 类 号：R511[医药卫生—内科学]