柚皮苷介导成骨细胞促进骨形成的机制研究进展  

Research Progress on the Mechanism of Naringin Mediating Osteoblast to Promote Bone Formation

作　　者：金环 何紫移 沈霖[2] 马陈 帅波 JIN Huan;HE Ziyi;SHEN Lin;MA Chen;SHUAI Bo(Wuhan Sports University,Wuhan 430079,China;Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China.)

机构地区：[1]武汉体育学院,武汉430079 [2]华中科技大学同济医学院附属协和医院

出　　处：《中国中医骨伤科杂志》2024年第8期92-96,共5页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：国家自然科学基金资助项目(82174182,81974546,82004201);中央高校基本科研业务费专项资金资助项目(2019kfyRCPY093)。

摘　　要：骨质疏松症(Osteoporosis,OP)是一种全身代谢性疾病,主要由骨吸收与骨形成之间的不平衡所引起。近年来,中药骨碎补组方的补肾强骨方抗骨质疏松症的临床疗效确切,其主要活性成分柚皮苷可调控成骨细胞分化,促进骨形成,进而在骨重建中发挥重要作用。中药活性成分及衍生物是目前开发抗骨质疏松症原创药物的创新途径之一,本文总结柚皮苷介导成骨细胞促进骨形成机制方面的研究进展,以期为临床开发抗骨质疏松症原研药物提供理论基础。总结了目前的最新研究,发现柚皮苷主要通过MAPK通路、SDF-1/CXCR4通路、PI3K/AKT通路、Wnt/β-catenin通路以及雌激素受体通路调控成骨细胞、促进骨形成,重点针对以上5条信号通路进行综述。Osteoporosis(OP)is a systemic metabolic disease caused by an imbalance between bone resorption and bone formation.In recent years,the Bushen,gluten-bone prescription of Fortune’s Drynaria Rhizome Decoction has definite clinical efficacy against OP.Naringin,its main active ingredient,can effectively regulate the differentiation of osteoblasts and promote bone formation,thus playing an important role in bone reconstruction.The active ingredients and derivatives of traditional Chinese medicine are one of the innovative ways to develop original anti-OP drugs.In this paper,the mechanism of naringin mediating osteoblasts to promote bone formation was discussed and summarized in order to provide theoretical basis for clinical development of anti-OP drugs.This paper summarizes the latest studies and finds that naringin mainly regulates osteoblasts to promote bone formation through MAPK pathway,SDF-1/CXCR4pathway,PI3K/AKT pathway,Wnt/β-catenin pathway and ER pathway.This paper will focus on the above 5signaling pathways.

关 键 词：柚皮苷 骨质疏松症 成骨细胞 信号通路 分子机制 

分 类 号：R68[医药卫生—骨科学]