用于多模态非线性光学显微成像的增益管理放大全光纤飞秒激光技术  

Development of Gain-managed Amplification All-fiber Femtosecond Laser Technology for Multimode Nonlinear Optics Imaging

作　　者：雷如梦 李中超 李孝燊 苏俊昌 刘伟[2] LEI Rumeng;LI Zhongchao;LI Xiaoshen;SU Junchang;LIU Wei(School of Physics and Astronomy,Sun Yat-sen University,Zhuhai 519000,China;College of Sciences,Sun Yat-sen University,Shenzhen 518000,China;Institute of Advanced Science Facilities,Shenzhen 518000,China)

机构地区：[1]中山大学物理与天文学院,珠海519000 [2]中山大学理学院,深圳518000 [3]深圳综合粒子设施研究院,深圳518000

出　　处：《光子学报》2024年第8期130-139,共10页Acta Photonica Sinica

基　　金：国家自然科学基金(No.1217050747)。

摘　　要：基于增益管理非线性放大的机制,求解非线性薛定谔方程和速率方程对脉冲在增益光纤中的传播过程进行仿真,研究了脉冲在增益光纤中的演化过程。结果表明,优化预啁啾量和种子光强度,可改变脉冲在增益光纤中的增益曲线。在动态增益曲线与非线性效应的共同作用下,输出光脉冲的频谱会迅速展宽数倍并带有线性啁啾,进而脉冲可被压缩至近傅里叶变换极限。为验证该超短脉冲产生方式的可行性,采用仿真结果中的最佳参数设置,成功设计并搭建了一台高能量、短脉宽、高质量的超快光纤光源。该光源可实现中心波长为1060 nm、重复频率为35 MHz、平均功率为267.4 mW以及脉冲宽度仅为39.5 fs的激光输出,与仿真结果高度一致。同现有的超短脉冲产生方式相比,本实验装置的结构更简单、造价更低、装置更紧凑、产生光束品质更佳。Multimodal Nonlinear Optical Imaging(NLOI)has revolutionized biological research by enabling high-resolution,three-dimensional fluorescence imaging with minimal cell phototoxicity.Unlike traditional microscopes using ultraviolet or visible light,NLOI employs near-infrared wavelengths(700~1100 nm),maximizing tissue penetration and minimizing photodamage.N LOI r elies o n femtosecond lasers to excite fluorescent markers like Green Fluorescent Protein(GFP).Despite their excellent performance,existing high-repetition-rate light sources,often tunable modelocked Titanium:Sapphire lasers,face limitations in generating high-peak power pulses at low exposure powers.This restricts their capabilities for deep tissue imaging.Fiber lasers,offer a compelling solution.Our novel fiber laser setup,based on Gain-Managed Amplification(GMA),addresses these limitations,generating high-quality,ultrashort femtosecond pulses ideal for NLOI.This compact and costeffective system boasts outstanding features:a 35 MHz repetition rate,39.5 fs pulse width,and 267.4 mW average power.Significantly broadening the spectrum(∼80 nm)and achieving near-Fourier-transformlimited pulses after compression,it surpasses conventional methods in both performance and affordability.Detailed simulations using the Generalized Nonlinear Schrödinger Equation(GNLSE)guided the optimal design of our setup,ensuring precise control over pulse propagation and optimizing pulse compression quality.We demonstrate the success of our approach by constructing an all-fiberized experiment setup encompassing seed source,pre-chirp management,GMA,and pulse compression modules.This innovative fiber laser holds immense potential for advancing NLOI applications,particularly in deep tissue cell imaging.We investigated the effects of different pre-chirp Group-Delay Dispersion(GDD)and seed energy on the output results using Fiberdesk software.The results indicate that input parameters with varying positive and negative pre-chirping GDD lead to a broader spectral broadening compared to

关 键 词：多模态非线性光学显微成像 增益管理非线性放大 线性啁啾 极端光谱展宽 超短脉冲 

分 类 号：TN248[电子电信—物理电子学]