不同种族高血压与骨质疏松症之间的关系  

Relationship between hypertension and osteoporosis in different racial groups

作　　者：张艺博 卢健棋[2] 毛美玲 陈丽丹 陆微 张政 张蕴力 陈佳永 Zhang Yibo;Lu Jianqi;Mao Meiling;Chen Lidan;Lu Wei;Zhang Zheng;Zhang Yunli;Chen Jiayong(Guangxi University of Chinese Medicine Graduate School,Nanning 530000,Guangxi Zhuang Autonomous Region,China;Department of Cardiology,the First Affiliated Hospital of Guangxi University of Chinese Medicine,the Sub-center of the National Clinical Medical Research Center for Cardiovascular Diseases of Traditional Chinese Medicine,Nanning 530000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西中医药大学研究生院,广西壮族自治区南宁市530000 [2]广西中医药大学第一附属医院心内科,国家中医心血管病临床医学研究中心分中心,广西壮族自治区南宁市530000

出　　处：《中国组织工程研究》2025年第12期2614-2622,共9页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金地区基金(82160887),项目负责人:卢健棋;国家自然科学基金面上项目(81673891),项目负责人:卢健棋;国家中医药管理局国家中医临床研究基地业务建设科研专攻课题(JDZX2015146),项目负责人:卢健棋;广西自然科学基金项目(2021JJA140661,2021GXNSFBA196018),项目负责人:卢健棋。

摘　　要：背景:多项临床研究观察表明高血压与骨质疏松症之间存在密切关系,但是高血压与骨质疏松症的因果关系尚不清楚。目的:采用全面的两样本孟德尔随机化分析,分别确定亚洲人群和欧洲人群中高血压与骨质疏松症、多部位骨密度和伴有骨折的骨质疏松症之间是否存在因果关系。方法:亚洲人群骨质疏松症数据通过日本生物银行获得,欧洲人群骨质疏松症数据从英国生物银行(UKBB)获得,高血压、多部位骨密度和伴有骨折的骨质疏松症数据均来自于FinnGen R10数据库。采用逆方差加权法、MR-Egger回归法、加权中位数法、加权模型法和简单模型法来研究亚洲人群和欧洲人群中高血压与骨质疏松症、多部位骨密度和伴有骨折的骨质疏松症之间的因果关系;应用综合敏感性分析验证结果的稳健性、异质性和水平多效性;通过Stsiger检测判断骨质疏松症与高血压之间有无反向因果关系。结果与结论:①在亚洲人群中,高血压与骨质疏松症之间没有显著的基因预测因果关系,高血压与跟骨骨密度之间呈正向因果关系;在欧洲人群中,高血压与骨质疏松症呈负向因果关系,与全身骨密度、跟骨骨密度、前臂骨密度及伴有骨折的骨质疏松症之间没有显著的因果关系;②通过Stsiger检测,判断亚洲人群和欧洲人群骨质疏松症、多部位骨密度和伴有骨折的骨质疏松症与高血压之间无反向因果关系;③结果证实:高血压与骨质疏松症之间存在因果关系,即在亚洲人群中,高血压与跟骨骨密度呈正向因果关系;在欧洲人群中,高血压与骨质疏松症呈负向因果关系,但未发现反向因果关联。BACKGROUND:Observations from several clinical studies suggest a close relationship between hypertension and osteoporosis,but the causal relationship between hypertension and osteoporosis is unclear.OBJECTIVE:To determine whether there is a causal relationship between hypertension and osteoporosis,multisite bone mineral density and osteoporosis with fractures in Asian and European populations,respectively,using a comprehensive two-sample Mendelian randomized analysis.METHODS:Data of osteoporosis in Asian populations were obtained through Japan biological bank.Data of osteoporosis in European populations were obtained from UK Biobank,a British biological bank.Data of hypertension,multisite bone mineral density and osteoporosis with fractures were all from FinnGen R10 database.Inverse variance weighted method,MR-Egger regression method,weighted median method,weighted model method and simple model method were used to study the causal relationship between hypertension and osteoporosis,multisite bone mineral density and osteoporosis with fracture in Asian and European populations.Comprehensive sensitivity analysis was used to verify the robustness,heterogeneity and level pleiotropy of the results.Stsiger test was used to determine whether there was a reverse causal relationship between osteoporosis and hypertension.RESULTS AND CONCLUSION:In Asian populations,there was no significant genetic predictive causal relationship between hypertension and osteoporosis,and there was a positive causal relationship between hypertension and calcaneal bone mineral density.In European populations,hypertension had a negative causal relationship with osteoporosis,and there was no significant causal relationship between hypertension and systemic bone mineral density,calcaneal bone mineral density,forearm bone mineral density and osteoporosis with fracture.According to the stsiger test,there was no reverse causal relationship between osteoporosis,multiplesite bone mineral density,osteoporosis with fracture and hypertension in Asian and Eu

关 键 词：高血压 骨质疏松症 孟德尔随机化 因果关系 骨密度 骨折 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R683