^(129)Xe通气功能MRI与肺部病灶类型关联研究  

Association of^(129)Xe Ventilation Functional MRI with Pulmonary Lesion Types

作　　者：陈琪 李海东 方媛 沈路阳 刘无己 罗明 李业成 张鸣 赵修超 石磊 周倩 韩叶清 周欣 CHEN Qi;LI Haidong;FANG Yuan;SHEN Luyang;LIU Wuji;LUO Ming;LI Yecheng;ZHANG Ming;ZHAO Xiuchao;SHI Lei;ZHOU Qian;HAN Yeqing;ZHOU Xin(State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,National Center for Magnetic Resonance in Wuhan,Innovation Academy for Precision Measurement Science and Technology,Chinese Academy of Sciences,Wuhan 430071,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]波谱与原子分子物理国家重点实验室,武汉磁共振中心,中国科学院精密测量科学与技术创新研究院,湖北武汉430071 [2]中国科学院大学,北京100049

出　　处：《波谱学杂志》2024年第3期276-285,共10页Chinese Journal of Magnetic Resonance

基　　金：国家自然科学基金项目(82127802,21921004,82372150,82202119);国家重点研发计划项目(2018YFA0704000,2022YFC2410-000);湖北省科技重大专项(2021ACA013,2023BAA021);中国科学院重点项目(ZDBS-LY-JSC004,XDB0540000);中国科学院青年促进会项目(2020330,2021330).

摘　　要：本研究旨在探索^(129)Xe通气功能MRI与肺部病灶类型之间的关联.我们对143例患者进行^(129)Xe通气功能MRI和肺部CT扫描,并分析了肺叶水平的通气功能与肺部病灶类型之间的关系.结果显示,大部分肺叶(74.6%)^(129)Xe肺通气功能MRI和CT结果一致.通气功能损伤与CT病灶类型相关,且混合疾病和肺气肿/肺大疱更易引起肺通气功能障碍.此外,我们的研究显示不同肺部病灶类型会呈现出不同的通气模式.即^(129)Xe通气功能MRI和肺部CT能够提供互补信息.本研究的初步结果将为肺部病灶引起的通气功能损伤评估提供数据支持,为临床影像学诊断提供更多的参考依据,有助于优化肺部疾病的诊断和治疗.This study investigates the correlation between^(129)Xe ventilation functional MRI and CT-detected pulmonary lesion types.We performed^(129)Xe ventilation functional MRI and CT scans on a sample of 143 patients,subsequently analyzing the relationship between lung ventilation function at the lobe level and CT lesion types.The findings suggest that the ventilation function from^(129)Xe MRI was consistent with CT results in the majority of lung lobes(74.6%).The ventilation function impairment of lung correlates with CT lesion types,particularly in instances of mixed diseases and emphysema/bullae,which are more prone to induce lung ventilation dysfunction.Moreover,distinct ventilation patterns are observed among different lesion types.That is,the data from both^(129)Xe ventilation functional MRI and CT provide complementary insights.The preliminary finding of this study offers data support for evaluating lung ventilation function caused by lung lesions,and provides more references for clinical imaging diagnosis,thereby contributing to the refinement of diagnostic and therapeutic strategies for pulmonary diseases.

关 键 词：超极化^(129)Xe 肺部通气功能磁共振成像 肺部CT 肺部疾病 

分 类 号：O482.53[理学—固体物理]