羊口疮病毒基因组结构及重要基因功能研究进展  

Progress in research on genome structure and important gene function of the orf virus

作　　者：张江绒 田谦 王艳华[1] 周洛译 孙跃峰 王光祥[1] ZHANG Jiangrong;TIAN Qian;WANG Yanhua;ZHOU Luoyi;SUN Yuefeng;WANG Guangxiang(State Key Laboratory of Veterinary Etiological Biology,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046,China)

机构地区：[1]中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室,甘肃兰州730046

出　　处：《畜牧与兽医》2024年第9期142-151,共10页Animal Husbandry & Veterinary Medicine

基　　金：重大跨境动物传染病快速诊断方法的创制与应用项目(21YF5WA153)。

摘　　要：羊口疮是由羊口疮病毒(orf virus, ORFV)引起的一种人畜共患疾病,具有接触性、嗜上皮性和自限性的特征,该疾病在全球范围内广泛流行,严重影响公共卫生,对养羊业也造成不可忽视的经济损失。本文主要综述了国内外在羊口疮病原学、基因组结构以及功能基因等方面的研究进展,旨在为相关学者提供研究参考。通过对病毒基因组及其功能基因的深入解析,不仅有助于深入理解病毒的致病机理和宿主的互作机制,同时也为疫苗的研发提供理论依据。Orf,caused by the orf virus(ORFV),is a zoonotic disease characterized by its contact,epitheliotropic,and self-limiting features.The disease is widely prevalent globally,severely threatening public health and causing significant economic losses to the sheep industry.This article mainly reviews the progress in research on the etiology,genomic structure,and functional genes of orf,both domestically and internationally,aiming to provide research references for relevant scholars.Through in-depth analysis of the viral genome and its functional genes,this paper not only contributes to a better understanding of the pathogenic mechanism of the virus and its interaction with the host,but also lays a theoretical foundation for development of related vaccines.

关 键 词：羊口疮 羊口疮病毒 功能基因 

分 类 号：S855.3[农业科学—临床兽医学]