Infection and Genomic Characteristics of Campylobacter jejuni from a Patient Without Diarrhea—China,2018  

作　　者：Xiangdong Yang Wen Wang Chajin Cui Binbin Yu Qing Zhang Yanhua Wang 

机构地区：[1]Ecological Medicine Research Center,National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing,China [2]Department of Zoonotic Disease Control and Prevention,Yunnan Institute of Endemic Diseases Control&Prevention,Dali Bai Autonomous Prefecture,Yunnan Province,China [3]Medical Laboratory Department,Yunnan Luxi County People’s Hospital,Honghe Hani-Yi Autonomous Prefecture,Yunnan Province,China

出　　处：《China CDC weekly》2024年第33期846-851,I0001-I0005,共11页中国疾病预防控制中心周报（英文）

基　　金：Supported by the National Natural Science Foundation of China (Grant No. 81874275 and 82102390);the Natural Science Foundation of Beijing Municipality (Grant No. 7242188)。

摘　　要：What is already known about this topic?A 20-month-old boy was admitted to the hospital with a maximum temperature of 40°C and a single convulsion.Unexpectedly,blood culture detected Francisella tularensis(F.tularensis)using the VITEK 2 Compact System.What is added by this report?After incubation of the patient’s blood for 48 hours,the cultured strain was identified as Campylobacter jejuni,named L8,excluding F.tularensis.In the genome sequence of L8,we found a novel Type VI Secretion System(T6SS),of which the conserved C-terminal VgrG domain from positions 561 to 884 showed significant changes.What are the implications for public health practice?It should be underscored that relying solely on automatic bacterial identification instruments for accurate strain identification is unreliable.Moreover,our study suggests that the potential effect of T6SS should be considered when studying the genetic features of a patient’s clinical phenotypes.

关 键 词：CAMPYLOBACTER admitted CULTURE 

分 类 号：R18[医药卫生—流行病学] R51[医药卫生—公共卫生与预防医学]