Potential Adverse Outcome Pathways of Chlorinated Organophosphate Flame Retardants  

作　　者：Meiyu Zhou Huilin Zhang Qi Xiao Kexin Li Xiaoting Li Haiyan Chu 

机构地区：[1]Department of Environmental Genomics,Jiangsu Key Laboratory of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Cancer Personalized Medicine,School of Public Health,Nanjing Medical University,Nanjing City,Jiangsu Province,China [2]Department of Genetic Toxicology,The Key Laboratory of Modern Toxicology of Ministry of Education,Center of Global Health,School of Public Health,Nanjing Medical University,Nanjing City,Jiangsu Province,China [3]Department of Nutrition and Food Safety,School of Public Health,Nanjing Medical University,Nanjing City,Jiangsu Province,China

出　　处：《China CDC weekly》2024年第23期542-546,I0008-I0011,共9页中国疾病预防控制中心周报（英文）

基　　金：Supported by the Natural Science Foundation of Jiangsu Province(grant number 22KJA330002);Collaborative Innovation Center for Cancer Personalized Medicine;the Priority Academic Program Development of Jiangsu Higher Education Institutions in the Field of Public Health and Preventive Medicine.

摘　　要：What is already known about this topic?Chlorinated organophosphate flame retardants(Cl-OPFRs)are frequently detected chemicals in the environment and biological samples,yet there is a lack of systematic evaluation regarding the adverse effects and toxicological mechanisms of Cl-OPFRs.What is added by this report?This study utilizes the adverse outcome pathway(AOP)framework to assess the health implications and mechanisms of Cl-OPFRs,identifying multi-system toxicity,with a particular emphasis on reproductive issues and the possible toxic mechanisms.What are the implications for public health practice?These results enhance knowledge of the health hazards linked to Cl-OPFRs,supporting the creation of focused risk evaluations and suitable regulatory actions.

关 键 词：utilize SUPPORTING CHLORIN 

分 类 号：R14[医药卫生—公共卫生与预防医学]