新型抗抑郁药托鲁地文拉法辛  

A novel antidepressant toludesvenlafaxine

作　　者：周琬琰 吕钦谕[1,2] 易正辉 ZHOU Wan-yan;LÜQin-yu;YI Zheng-hui(Department of Psychiatry,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,SHANGHAI 200030,China;Department of Psychiatry,Huashan Hospital,Fudan University,SHANGHAI 200040,China;Institute of Mental Health,Fudan University,SHANGHAI 200040,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心精神科,上海200030 [2]复旦大学附属华山医院精神科,上海200040 [3]复旦大学精神卫生研究院,上海200040

出　　处：《中国新药与临床杂志》2024年第7期514-517,共4页Chinese Journal of New Drugs and Clinical Remedies

基　　金：科技创新2030“脑科学与类脑研究”重大项目(2022ZD0208500)。

摘　　要：新型抗抑郁药托鲁地文拉法辛,又名安舒法辛,是我国自主研发的一种三重单胺类再摄取抑制剂,可通过与5-羟色胺转运体、去甲肾上腺素转运体和多巴胺转运体结合,阻断以上3种神经递质的再摄取而发挥抗抑郁作用。该药起效较快,能够显著改善抑郁障碍患者的心境低落、快感缺失、动力下降等症状,缓解伴发的焦虑症状,且治疗过程中不易导致性功能障碍等不良反应。临床在使用该药时应注意从小剂量开始,同时对患者进行转躁风险的评估和管理。由于该药可作用于多巴胺通路,临床还需关注治疗中是否会引起患者的精神病性症状。The new antidepressant toludesvenlafaxine,also known as ansofaxine,is a triple monoaminergic reuptake inhibitor independently developed in China.It can play an antidepressant effects by blocking the reuptake of the three neurotransmitters by combining with the serotonin transporter,noradrenaline,and dopamine transporter.Toludesvenlafaxine has a rapid effect,which can significantly improve the low mood,anhedonia,lack of motivation and other symptoms of patients with depressive disorders,relieve the associated anxiety symptoms,and is not easy to lead to sexual dysfunction and other adverse reactions in the treatment process.While using toludesvenlafaxine,clinicians should start titration with a low dose and assess the risk of mania during the course of treatment,and pay attention to whether the drug could cause psychotic symptoms,since it acts on the dopamine pathway.

关 键 词：托鲁地文拉法辛 抗抑郁药 多巴胺摄取抑制剂 肾上腺素能摄取抑制剂 

分 类 号：R971.4[医药卫生—药品]