整合素相互作用蛋白Kindlin-2可作为非小细胞肺癌不良预后因子  

Integrin Interacting Protein Kindlin-2 Predict Poor Prognosis in Non-small Cell Lung Cancer Patients

作　　者：张琼霞[1] 陈树鹏 苏琼菲 秦鑫添[1] ZHANG Qiongxia;CHEN Shupeng;SU Qiongfei;QIN Xintian(Department of Oncology,The First Affiliated Hospital of Guangdong Pharmaceutical University,Guangzhou,Guangdong 510080,China;State Key Laboratory of Oncology in South China,Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong 510080,China)

机构地区：[1]广东药科大学附属第一医院,广东广州510080 [2]中山大学附属肿瘤医院,广东广州510080

出　　处：《今日药学》2024年第7期517-520,共4页Pharmacy Today

基　　金：广东省医学科学技术研究基金项目(B2021381);广东省中医药局科研项目(20212105)。

摘　　要：目的 研究整合素相互作用蛋白Kindlin-2在非小细胞肺癌组织中的表达及其与非小肺癌患者预后的相关性。方法 查阅2008~2018年在某院接受手术的256例非小细胞肺癌患者病历资料,收集相对应的组织蜡块标本,采用免疫组化方法 检测Kindlin-2的表达并评分。检测Kindlin-2表达情况与非小细胞肺癌预后的关系。结果 Kindlin-2在非小细胞肺癌组织中的高表达率约51.6%(132/256)。单因素和多因素分析均已表明Kindlin-2可以作为非小细胞肺癌总生存的独立预后因子。结论 Kindlin-2在非小细胞肺癌组织中高表达,在非小细胞肺癌中Kindlin-2可以作为其独立预后不良因子。OBJECTIVE Investigate the expression of integrin interacting protein Kindlin-2 in non-small cell lung cancer(NSCLC) and its correlation with the prognosis of non-small cell lung cancer patients.METHODS Reviewing the medical records of 256 patients with non-small cell lung cancer who underwent surgery in a hospital from 2008 to 2018.Wax samples of non-small cell lung cancer tissues were collected,and the expression of Kindlin-2 was detected and scored by immunohistochemical method. To investigate the relationship between Kindlin-2 expression and prognosis of non-small cell lung cancer.RESULTS The high expression rate of Kindlin-2 in non-small cell lung cancer tissues was approximately 51.6%(132/256). Both univariate and multivariate analyses indicated that Kindlin-2 could be used as an independent prognostic factor for OS in non-small cell lung cancer patients.CONCLUSION Kindlin-2 is highly expressed in non-small cell lung cancer tissues,and overexpression of Kindlin-2 can be used as an independent prognostic factor for non-small cell lung cancer.

关 键 词：整合素相互作用蛋白 Kindlin-2 非小细胞肺癌 预后因子 

分 类 号：R966[医药卫生—药理学]