簕菜化学成分和药理活性的研究进展  

Research Progress on Chemical Constituents and Pharmacological Activities of Acanthopanax trifoliatus(L.)Merr

作　　者：吴俊洪 梁少瑜[1,2] 徐丹丹 曾永长 吴正治[1,2] WU Junhong;LIANG Shaoyu;XU Dandan;ZENG Yongchang;WU Zhengzhi(Institute of Translational Medicine,the First Affiliated Hospital of Shenzhen University,Shenzhen,Guangdong 518035,China;Shenzhen Institute of Geriatrics,Shenzhen,Guangdong 518035,China;Guizhou University of Traditional Chinese Medicine,Guiyang,Guizhou 550025,China)

机构地区：[1]深圳大学第一附属医院转化医学研究院,广东深圳518035 [2]深圳市老年医学研究所,广东深圳518035 [3]贵州中医药大学,贵州贵阳550025

出　　处：《今日药学》2024年第8期619-629,共11页Pharmacy Today

基　　金：广东省自然科学基金(2021A1515010978,2021A1515012474);深圳市科技计划项目(JCYJ20180227175929767,JCYJ20210324121610029);广东省重点领域研发计划项目(2020B1111120003)。

摘　　要：簕菜是五加科(Araliaceae)五加属(Acanthopanax)的攀援灌木,为药食两用植物,含有萜类、酚类、多糖、黄酮、甾体、有机酸和脂肪烃等成分,其中二萜类、三萜类、酚类和多糖是主要活性成分。现代药理研究发现,簕菜具有抗炎镇痛、抗氧化、降血糖、抗肿瘤、抑菌和改善认知等活性。本文基于近年来公开发表的文献,对簕菜的化学成分和药理活性进行归纳和梳理,旨在为其深入研究和开发提供参考。Acanthopanax trifoliatus(L.)Merr,is a medicinal and edible plant containing terpenoids,phenols,polysaccharides,flavonoids,steroids,organic acids and aliphatic hydrocarbons,in which diterpenes,triterpenes,phenols and polysaccharides are the main active components.Modern pharmacological studies have found that A.trifoliatus has anti-inflammatory,analgesic,antioxidant,hypoglycemic,anti-tumor,antibacterial and cognitive improvement effects.Based on the published literature in recent years,this paper summarizes the chemical constituents and pharmacological actions of A.trifoliatus,in order to provide reference for its further research and development.

关 键 词：簕菜 化学成分 萜类 多糖 药理活性 抗肿瘤 

分 类 号：R285[医药卫生—中药学]